Abamectin( Abamectin, Affirm, Avid, Avid EC, Avomec, EPA Pesticide Chemical Code 122804, HSDB 6941, MK 0936 )

Catalog No. M15742 CAS No. 71751-41-2

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Product Name

Abamectin
Note

Research use only, not for human use.
Brief Description

Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic.
Description

Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic.
In Vitro

Cell Viability Assay Cell Line:Mouse embryonic fibroblast (MEF) cells Concentration:0, 0.5, 5, 10, 20, 40, 80 μM Incubation Time:12 h Result:Reduced cell viability with an IC50 value of 45.6 μM.Western Blot Analysis Cell Line:MGC803 cells Concentration:0-4 μM Incubation Time:24 h Result:Increased active caspase-3 and expression of Bax/Bcl-2, decreased MMP in a dose-dependent manner.
In Vivo

Animal Model:Horses (had a pruritic dermatosis)Dosage:0.2 mg/kg, a single dose.Administration:Oral administration Result:Decreased in mean strongyle egg counts 14, 28 and 42 d after treatment, and resulted in zero microfilaria counts in all horses 14 d after treatment.Animal Model:Healthy adult female sheep (Pharmacokinetic assay)Dosage:0.2 mg/kg Administration:Subcutaneous administration (in the left neck area of each sheep)Result:Pharmacokinetic profiles of Avermectin B1.
Synonyms

Abamectin, Affirm, Avid, Avid EC, Avomec, EPA Pesticide Chemical Code 122804, HSDB 6941, MK 0936
Pathway

Others
Target

Other Targets
Recptor

Antiparasitic
Research Area

Infection
Indication

——

CAS Number

71751-41-2
Formula Weight

873.09
Molecular Formula

C48H72O14
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

C[C@H]1[C@H](O)[C@@H](OC)C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]([C@@H](C)/C=C/C=C3CO[C@@]4([H])[C@]\3(O)[C@@]5([H])C=C(C)[C@H]4O)/C(C)=C/C[C@]6([H])C[C@H](OC5=O)C[C@@]7(O[C@H](C(C)C)[C@@H](C)C=C7)O6)C[C@@H]2OC)O1.C[C@H]8[C@H](O)[C@@H](OC)C[C@H](O[C@H]9[C@H](C)O[C@@H](O[C@@H]([C@@H](C)/C=C/C=C%10CO[C@@]%11([H])[C@]\%10(O)[C@@]%12([H])C=C(C)[C@H]%11O)/C(C)=C/C[C@]%13([H])C[C@H](OC%12=O)C[C@@]%14(O[C@H]([C@@H](CC)C)[C@@H](C)C=C%14)O%13)C[C@@H]9OC)O8
Chemical Name

Avermectin B(sub 1)

1.Mogg TD, et al. Aust Vet J. 1990 Nov;67(11):399-40

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