AZD9898( —— )

Catalog No. M26621 CAS No. 2042347-69-1

AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 has the potential to treat asthma. AZD9898 mitigates the GABA binding and hepatic toxicity signal.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

AZD9898
Note

Research use only, not for human use.
Brief Description

AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 has the potential to treat asthma. AZD9898 mitigates the GABA binding and hepatic toxicity signal.
Description

AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 has the potential to treat asthma. AZD9898 mitigates the GABA binding and hepatic toxicity signal.(In Vivo):AZD9898 (10 and 100 mg/kg; oral) is well tolerated and shows no safety concerns.
In Vitro

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In Vivo

AZD9898 with the single dose of 100 mg/kg is well tolerated and no safety concerns are raised. Animal Model:Rat 6M/group.Dosage:10 and 100 mg/kg (for Toxicology Study).Administration:Sing oral dose.Result:Showed no signs of testicular toxicity, and only adaptive changes in the liver due to cytochrome P450 induction which were not judged adverse, providing a 200 fold margin between the no adverse effect level and the predicted human exposure at the predicted therapeutic dose.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Antifungal
Research Area

——
Indication

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Chemical Information

CAS Number

2042347-69-1
Formula Weight

457.83
Molecular Formula

C20H19ClF3N3O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 250 mg/mL (546.05 mM)
SMILES

COc1nc(cnc1C(=O)[C@H]1C[C@@H]1C(O)=O)N(CC(C)(C)F)c1cc(Cl)c(F)cc1F
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.S Boukaew, et al. Efficacy of volatile compounds from Streptomyces philanthi RL-1-178 as a biofumigant for controlling growth and aflatoxin production of the two aflatoxin-producing fungi on stored soybean seeds. J Appl Microbiol. 2020 Sep;129(3):652-664.

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