
AZD5462
CAS No. 2787501-83-9
AZD5462( —— )
Catalog No. M35747 CAS No. 2787501-83-9
AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 567 | In Stock |
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5MG | 850 | In Stock |
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10MG | 1207 | In Stock |
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25MG | 1822 | In Stock |
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50MG | 2558 | In Stock |
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100MG | 3168 | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameAZD5462
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NoteResearch use only, not for human use.
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Brief DescriptionAZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.
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DescriptionAZD5462 is a RXFP1 modulator, can be used for heart failure research. RXFP1 is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties.
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In VitroAZD5462 (example 1) shows stimulatory activity on cAMP or cGMP production with EC50s of 17 nM and 50 nM, respectively.AZD5462 binds human plasma protein with fraction unbound (free) rate of 4.3%, and shows the stability with Clint values of 23 μL/min/mg (human licer microsomal), 4.8 μL/min/106 cells (human hepatocyte), and 11 μL/min/106 cells (rat hepatocyte).AZD5462 enhances phosphorylation of ERK with an EC50 value of 6.3 nM.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorRXFP receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2787501-83-9
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Formula Weight544.65
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Molecular FormulaC30H41FN2O6
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Purity>98% (HPLC)
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Solubility——
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SMILESC(NCC1(C)CCC1)(=O)[C@@H]2[C@H](NC(=O)C3=C(OC)C=C(F)C(O[C@H]4CC[C@](C(O)=O)(C)CC4)=C3)[C@@]5(C[C@]2(CC5)[H])[H]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Granberg Kenneth Lars, et al. 4-(2-Fluoro-4-methoxy-5-(3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid derivatives and similar compounds as RXFP1 modulators for the treatment of heart failure and their preparation: World Intellectual Property Organization, WO2022122773. 2022-06-16.
molnova catalog



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