Cart
sales@molnova.com
Home - Products - Apoptosis - Apoptosis - AZD-4877

AZD-4877

CAS No. 758722-49-5

AZD-4877( —— )

Catalog No. M37653 CAS No. 758722-49-5

AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and mediates apoptosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 369 Get Quote
5MG 581 Get Quote
10MG 905 Get Quote
25MG 1408 Get Quote
50MG 1822 Get Quote
100MG 2502 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    AZD-4877
  • Note
    Research use only, not for human use.
  • Brief Description
    AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and mediates apoptosis.
  • Description
    AZD4877 is another isostere to Ispinesib (HY-50759)and also a kinesin spindle protein (Eg5) inhibitor with IC50 of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity.
  • In Vitro
    Apoptosis Analysis Cell Line:UC1, UC3, UC6, UC12, UC15, RT4,JB,BV, T24 cell line Concentration:10 nM Incubation Time:24 or 48 hours Result:Induced apoptosis in human bladder cancer cells
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis | Kinesin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    758722-49-5
  • Formula Weight
    503.66
  • Molecular Formula
    C28H33N5O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(N(C(=O)C1=CC=C(C)C=C1)CCCN)(C(C)C)C=2N(CC3=CC=CC=C3)C(=O)C4=C(N2)SN=C4C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Theoclitou ME, et.al. Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent. J Med Chem. 2011 Oct 13;54(19):6734-50. ?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • LCH-7749944

    LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis.?

  • SACLAC

    SACLAC is a cysteine asparaginase activation inhibitor with antitumor activity that decreases AML cell viability, inhibits AML cell proliferation, increases AML cell death, and induces apoptosis of AML cells, and is used in the study of acute myeloid leukemia and cancer.

  • (-)-Epipodophyllotox...

    (-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro.

Sign In Join Free