Cart
sales@molnova.com
AZD-4877
CAS No. 758722-49-5
AZD-4877( —— )
Catalog No. M37653 CAS No. 758722-49-5
AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and mediates apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 369 | Get Quote |
|
| 5MG | 581 | Get Quote |
|
| 10MG | 905 | Get Quote |
|
| 25MG | 1408 | Get Quote |
|
| 50MG | 1822 | Get Quote |
|
| 100MG | 2502 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameAZD-4877
-
NoteResearch use only, not for human use.
-
Brief DescriptionAZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and mediates apoptosis.
-
DescriptionAZD4877 is another isostere to Ispinesib (HY-50759)and also a kinesin spindle protein (Eg5) inhibitor with IC50 of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity.
-
In VitroApoptosis Analysis Cell Line:UC1, UC3, UC6, UC12, UC15, RT4,JB,BV, T24 cell line Concentration:10 nM Incubation Time:24 or 48 hours Result:Induced apoptosis in human bladder cancer cells
-
In Vivo——
-
Synonyms——
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorApoptosis | Kinesin
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number758722-49-5
-
Formula Weight503.66
-
Molecular FormulaC28H33N5O2S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC(N(C(=O)C1=CC=C(C)C=C1)CCCN)(C(C)C)C=2N(CC3=CC=CC=C3)C(=O)C4=C(N2)SN=C4C
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Theoclitou ME, et.al. Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent. J Med Chem. 2011 Oct 13;54(19):6734-50. ?
molnova catalog
related products
-
Triparanol
Triparanol interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling.
-
Cardanol (C15:1)
Cardanol (C15:1), found in cashew nut shell liquid, induces mitochondria-associated apoptosis in human melanoma cells.
-
RAPTA-C
RAPTA-C induces EAC cell cycle arrest and apoptosis via the mitochondrial and p53-JNK pathways, and can be used in the study of breast and ovarian cancer.
