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AZD-0865
CAS No. 248919-64-4
AZD-0865( Linaprazan | AZD0865 | AZD 0865 )
Catalog No. M13729 CAS No. 248919-64-4
A potent, selective acid pump antagonist (potassium-competitive acid blocker or P-CAB) that reversiblely inhibits gastric H+/K+-ATPase with pIC50 of 6.5.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | Get Quote |
|
| 5MG | 65 | Get Quote |
|
| 10MG | 110 | Get Quote |
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| 25MG | 222 | Get Quote |
|
| 50MG | 335 | Get Quote |
|
| 100MG | 520 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAZD-0865
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective acid pump antagonist (potassium-competitive acid blocker or P-CAB) that reversiblely inhibits gastric H+/K+-ATPase with pIC50 of 6.5.
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DescriptionA potent, selective acid pump antagonist (potassium-competitive acid blocker or P-CAB) that reversiblely inhibits gastric H+/K+-ATPase with pIC50 of 6.5; inhibits H+/K+-ATPase activity in a K(+)-competitive manner with Ki of 46 nM, shows no ativity for porcine renal Na(+),K(+)-ATPase at 100 uM; inhibits gastric acid secretion in vivo.UlcerPhase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsLinaprazan | AZD0865 | AZD 0865
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PathwayMembrane Transporter/Ion Channel
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TargetProton Pump
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RecptorProton Pump
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Research AreaOther Indications
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IndicationUlcer
Chemical Information
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CAS Number248919-64-4
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Formula Weight366.4567
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Molecular FormulaC21H26N4O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 35 mg/mL
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SMILESCC1=C(C(=CC=C1)C)CNC2=CC(=CN3C2=NC(=C3C)C)C(=O)NCCO
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Chemical NameImidazo[1,2-a]pyridine-6-carboxamide, 8-[[(2,6-dimethylphenyl)methyl]amino]-N-(2-hydroxyethyl)-2,3-dimethyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bailey N, et al. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3602-6.
2. Gedda K, et al. Biochem Pharmacol. 2007 Jan 15;73(2):198-205.
3. Kirchhoff P, et al. Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G838-43.
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