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AZ876

CAS No. 898800-26-5

AZ876( —— )

Catalog No. M19966 CAS No. 898800-26-5

AZ876 is a potent highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZ876
  • Note
    Research use only, not for human use.
  • Brief Description
    AZ876 is a potent highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
  • Description
    AZ876 is a potent highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    LXR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    898800-26-5
  • Formula Weight
    439.57
  • Molecular Formula
    C24H29N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 2.5 mg/mL
  • SMILES
    CC(C)(C)N1C(=O)C(Nc2ccc(cc2)N2CCCCC2)=C(c2ccccc2)S1(=O)=O
  • Chemical Name
    2-(11-Dimethylethyl)-5-phenyl-4-[[4-(1-piperidinyl)phenyl]amino]-3(2H)-isothiazolone 11-dioxide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.van der Hoorn J et al. Low dose of the liver X receptor agonist AZ876 reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels. Br J Pharmacol. 2011 Apr;162(7):1553-63.
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