AZ5104 ( AZ5104; AZ-5104; AZ 5104. Demethylated AZ9291. metabolite of AZD9291 )

Catalog No. M11764 CAS No. 1421373-98-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

AZ5104
Note

Research use only, not for human use.
Brief Description

AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor.
Description

AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.
Synonyms

AZ5104; AZ-5104; AZ 5104. Demethylated AZ9291. metabolite of AZD9291
Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR (L858R); EGFR (L858R/T790M); EGFR (L861Q); EGFR (wildtype); HER2/ErbB2
Research Area

Cancer
Indication

——

CAS Number

1421373-98-9
Formula Weight

485.58
Molecular Formula

C27H31N7O2
Purity

>98%(HPLC)
Solubility

Ethanol: 23 mg/mL warmed (47.36 mM); DMSO: 97 mg/mL (199.76 mM)
SMILES

C=CC(NC1=CC(NC2=NC=CC(C3=CNC4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C)=O.
Chemical Name

N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide

1. Cross DA, et al. Y Discov. 2014, 4(9), 1046-1061.

Calculator

molnova catalog