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AZ5104
CAS No. 1421373-98-9
AZ5104 ( AZ5104; AZ-5104; AZ 5104. Demethylated AZ9291. metabolite of AZD9291 )
Catalog No. M11764 CAS No. 1421373-98-9
AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor.
Purity : >98%(HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 43 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 113 | In Stock |
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| 50MG | 203 | In Stock |
|
| 100MG | 273 | In Stock |
|
| 200MG | 405 | In Stock |
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| 500MG | 668 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAZ5104
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NoteResearch use only, not for human use.
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Brief DescriptionAZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor.
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DescriptionAZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.
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SynonymsAZ5104; AZ-5104; AZ 5104. Demethylated AZ9291. metabolite of AZD9291
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR (L858R); EGFR (L858R/T790M); EGFR (L861Q); EGFR (wildtype); HER2/ErbB2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1421373-98-9
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Formula Weight485.58
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Molecular FormulaC27H31N7O2
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Purity>98%(HPLC)
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SolubilityEthanol: 23 mg/mL warmed (47.36 mM); DMSO: 97 mg/mL (199.76 mM)
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SMILESC=CC(NC1=CC(NC2=NC=CC(C3=CNC4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C)=O.
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Chemical NameN-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cross DA, et al. Y Discov. 2014, 4(9), 1046-1061.
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