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AZ13705339
CAS No. 2016806-57-6
AZ13705339( AZ-13705339 | AZ 13705339 )
Catalog No. M27853 CAS No. 2016806-57-6
AZ13705339 is a potent and selective PAK1 inhibitor with IC50 of 0.33 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 35 | Get Quote |
|
| 5MG | 58 | Get Quote |
|
| 10MG | 88 | Get Quote |
|
| 25MG | 200 | Get Quote |
|
| 50MG | 320 | Get Quote |
|
| 100MG | 515 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAZ13705339
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NoteResearch use only, not for human use.
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Brief DescriptionAZ13705339 is a potent and selective PAK1 inhibitor with IC50 of 0.33 nM.
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DescriptionAZ13705339 is a potent and selective PAK1 inhibitor with IC50 of 0.33 nM.(In Vitro):AZ13705339 (300 nM) prevents Siglec-8 binding-induced eosinophil death. In Namalwa cells, AZ13705339 (1 μM) inhibits αIgM-controlled but not PMA-induced adhesion.(In Vivo):In rats, AZ13705339 (100 mg/kg, p.o.) exhibits moderate clearance and Cmax of 7.7 μM.
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In VitroAZ13705339 (1 μM) inhibits αIgM-controlled adhesion and not PMA-induced adhesion in Namalwa cells.AZ13705339 (300 nM, 30 min) prevents Siglec-8 engagement-induced eosinophil death.
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In VivoAZ13705339 (100 mg/kg, P.O.) has moderate clearance and oral Cmax of 7.7 μM in rats.
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SynonymsAZ-13705339 | AZ 13705339
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2016806-57-6
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Formula Weight629.76
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Molecular FormulaC33H36FN7O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (396.98 mM)
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SMILESCCS(=O)(=O)c1cc(Nc2ncc(F)c(n2)N(Cc2ccccc2C#N)c2cc(CO)ccc2C)ccc1N1CCN(C)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Andrew F Ducruet , et al. GM1485, a Nonimmunosuppressive Immunophilin Ligand, Promotes Neurofunctional Improvement and Neural Regeneration Following Stroke. J Neurosci Res. 2012 Jul;90(7):1413-23.
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