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AX20017
CAS No. 329221-38-7
AX20017( —— )
Catalog No. M20738 CAS No. 329221-38-7
AX20017 is a small-molecule protein kinase G (PknG) inhibitor(IC50 : 0.39 μM). It acts by blocking the proliferation of M. tuberculosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 39 | In Stock |
|
| 5MG | 59 | In Stock |
|
| 10MG | 83 | In Stock |
|
| 25MG | 178 | In Stock |
|
| 50MG | 309 | In Stock |
|
| 100MG | 464 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAX20017
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NoteResearch use only, not for human use.
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Brief DescriptionAX20017 is a small-molecule protein kinase G (PknG) inhibitor(IC50 : 0.39 μM). It acts by blocking the proliferation of M. tuberculosis.
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DescriptionAX20017 is a small-molecule protein kinase G (PknG) inhibitor(IC50 : 0.39 μM). It acts by blocking the proliferation of M. tuberculosis.(In Vitro):The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.
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In VitroThe compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPknG
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Research Area——
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Indication——
Chemical Information
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CAS Number329221-38-7
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Formula Weight264.34
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Molecular FormulaC13H16N2O2S
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Purity>98% (HPLC)
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SolubilityDMSO:32 mg/mL (121.06 mM)
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SMILESNC(=O)c1c(NC(=O)C2CC2)sc2CCCCc12
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Chemical Name2-(Cyclopropanecarbonylamino)-233a45677a-octahydro-1-benzothiophene-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Scherr N Honnappa S Kunz G et al. Structural basis for the specific inhibition of protein kinase G a virulence factor of Mycobacterium tuberculosis[J]. Proceedings of the National Academy of Sciences 2007 104(29):12151-12156.
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