Cart
sales@molnova.com
Home - Products - Others - Other Targets - AX20017

AX20017

CAS No. 329221-38-7

AX20017( —— )

Catalog No. M20738 CAS No. 329221-38-7

AX20017 is a small-molecule protein kinase G (PknG) inhibitor(IC50 : 0.39 μM). It acts by blocking the proliferation of M. tuberculosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 39 In Stock
5MG 59 In Stock
10MG 83 In Stock
25MG 178 In Stock
50MG 309 In Stock
100MG 464 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    AX20017
  • Note
    Research use only, not for human use.
  • Brief Description
    AX20017 is a small-molecule protein kinase G (PknG) inhibitor(IC50 : 0.39 μM). It acts by blocking the proliferation of M. tuberculosis.
  • Description
    AX20017 is a small-molecule protein kinase G (PknG) inhibitor(IC50 : 0.39 μM). It acts by blocking the proliferation of M. tuberculosis.(In Vitro):The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.
  • In Vitro
    The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PknG
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    329221-38-7
  • Formula Weight
    264.34
  • Molecular Formula
    C13H16N2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:32 mg/mL (121.06 mM)
  • SMILES
    NC(=O)c1c(NC(=O)C2CC2)sc2CCCCc12
  • Chemical Name
    2-(Cyclopropanecarbonylamino)-233a45677a-octahydro-1-benzothiophene-3-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Scherr N Honnappa S Kunz G et al. Structural basis for the specific inhibition of protein kinase G a virulence factor of Mycobacterium tuberculosis[J]. Proceedings of the National Academy of Sciences 2007 104(29):12151-12156.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • 6-(4-Hydroxy-3-methy...

    6-(4-Hydroxy-3-methylphenyl)-2-methylhept-2-en-4-one is a natural product for research related to life sciences.

  • Dynamin inhibitory p...

    Control peptide version of dynamin inhibitory peptide, myristoylated, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. In contrast to dynamin inhibitory peptide, has no significant effect on GABAA receptor-mediated miniature IPSPs.

  • AK301

    AK301 is a potent and selective inhibitor of tubulin polymerization and an effective sensitizer of cancer cells to apoptotic ligands (EC50 < 200 nM).

Sign In Join Free