AVN-211 ( AVN211;CD-008-0173 )

Catalog No. M10580 CAS No. 1173103-84-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AVN-211
Note

Research use only, not for human use.
Brief Description

AVN-211 (CD-008-0173) is a novel and highly selective 5-HT6 receptor small molecule antagonist with Ki of 2.34 nM.
Description

AVN-211 (CD-008-0173) is a novel and highly selective 5-HT6 receptor small molecule antagonist with Ki of 2.34 nM; shows a similar or better anxiolytic efficacy than fenobam, rufinamide, lorazepam, and buspirone in an elevated plus-maze model; significantly delayes or partially halts the progressive decline in memory function associated with AD.Schizophrenia Phase 3 Clinical
Synonyms

AVN211;CD-008-0173
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT Receptor
Research Area

Neurological Disease
Indication

Schizophrenia

CAS Number

1173103-84-8
Formula Weight

333.42
Molecular Formula

C15H15N3O2S2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=S(C1=C2N=C(C)C=C(C)N2N=C1SC)(C3=CC=CC=C3)=O
Chemical Name

5,7-Dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine

1. Ivachtchenko AV, et al. Mol Pharm. 2016 Mar 7;13(3):945-63.
2. Morozova MA,et al. CNS Spectr. 2014 Aug;19(4):316-23.

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