
AVG-233
CAS No. 2151937-80-1
AVG-233( —— )
Catalog No. M35708 CAS No. 2151937-80-1
AVG-233 is an orally available RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity that blocks respiratory syncytial virus and SARS-CoV-2 replication.AVG-233 is used in the study of respiratory syncytial virus infections.
Purity : >98% (HPLC)






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Biological Information
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Product NameAVG-233
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NoteResearch use only, not for human use.
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Brief DescriptionAVG-233 is an orally available RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity that blocks respiratory syncytial virus and SARS-CoV-2 replication.AVG-233 is used in the study of respiratory syncytial virus infections.
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DescriptionAVG-233 is a potent, orally active RNA dependent RNA polymerase (RdRp) inhibitor. AVG-233 prevents initiation of the viral polymerase complex at the promoter. AVG-233 binding site is present in the L1-1749 fragment. AVG-233 has nanomolar activity against both RSV strains and clinical RSV isolates (EC50=0.14-0.31 μM). AVG-233 can be used for research of respiratory syncytial virus (RSV).
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In Vitro——
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In VivoAnimal Model:Female Balb/cJ mice with recRSV-mKate xenograft Dosage:50 and 100 mg/kg Administration:Oral gavage; once Result:Reduced in lung viral load of 0.89 log10 TCID50 (median tissue culture infectious dose)/mL.Animal Model:Male CD-1 mice (27-29 g)Dosage:2 mg/kg (i.v.) and 20 mg/kg (p.o.) Administration:Intravenous injection and oral administration.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA/RNA Synthesis | RSV
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Research Area——
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Indication——
Chemical Information
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CAS Number2151937-80-1
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Formula Weight487.94
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Molecular FormulaC26H22ClN5O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (102.47 mM; Ultrasonic (<60°C)
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SMILESCOc1ccc(Cn2n(-c3ccccn3)c(=O)c3c(C)n(Cc4cccc(Cl)n4)c(=O)cc23)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cox RM, et, al. Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex. J Biol Chem. 2018 Oct 26;293(43):16761-16777.?
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