Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - AVG-233

AVG-233

CAS No. 2151937-80-1

AVG-233( —— )

Catalog No. M35708 CAS No. 2151937-80-1

AVG-233 is an orally available RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity that blocks respiratory syncytial virus and SARS-CoV-2 replication.AVG-233 is used in the study of respiratory syncytial virus infections.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 302 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    AVG-233
  • Note
    Research use only, not for human use.
  • Brief Description
    AVG-233 is an orally available RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity that blocks respiratory syncytial virus and SARS-CoV-2 replication.AVG-233 is used in the study of respiratory syncytial virus infections.
  • Description
    AVG-233 is a potent, orally active RNA dependent RNA polymerase (RdRp) inhibitor. AVG-233 prevents initiation of the viral polymerase complex at the promoter. AVG-233 binding site is present in the L1-1749 fragment. AVG-233 has nanomolar activity against both RSV strains and clinical RSV isolates (EC50=0.14-0.31 μM). AVG-233 can be used for research of respiratory syncytial virus (RSV).
  • In Vitro
    ——
  • In Vivo
    Animal Model:Female Balb/cJ mice with recRSV-mKate xenograft Dosage:50 and 100 mg/kg Administration:Oral gavage; once Result:Reduced in lung viral load of 0.89 log10 TCID50 (median tissue culture infectious dose)/mL.Animal Model:Male CD-1 mice (27-29 g)Dosage:2 mg/kg (i.v.) and 20 mg/kg (p.o.) Administration:Intravenous injection and oral administration.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA/RNA Synthesis | RSV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2151937-80-1
  • Formula Weight
    487.94
  • Molecular Formula
    C26H22ClN5O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (102.47 mM; Ultrasonic (<60°C)
  • SMILES
    COc1ccc(Cn2n(-c3ccccn3)c(=O)c3c(C)n(Cc4cccc(Cl)n4)c(=O)cc23)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cox RM, et, al. Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex. J Biol Chem. 2018 Oct 26;293(43):16761-16777.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • DDRI-18

    DDRI-18 is a novel small molecule inhibitor that regulates the DNA damage response with sensitizing and anticancer activities, inhibits non-homologous end-joining (NHEJ) DNA repair and enhances the cytotoxicity of anticancer DNA damage compounds.

  • CKK-E12

    CKK-E12 is a selective ionizable lipid that often binds to other lipids to form carrier mRNA lipid nanoparticles.CKK-E12 is used in the study of RNA-related diseases.

  • G150

    G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.

Sign In Join Free