
ATR-101
CAS No. 133825-81-7
ATR-101( PD-132301 | PD132301-2 | ATR 101 | Nevanimibe )
Catalog No. M11357 CAS No. 133825-81-7
ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM.
Purity : >98% (HPLC)






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5MG | 192 | In Stock |
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10MG | 267 | In Stock |
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25MG | 417 | In Stock |
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50MG | 533 | In Stock |
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100MG | 708 | In Stock |
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Biological Information
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Product NameATR-101
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NoteResearch use only, not for human use.
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Brief DescriptionATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM.
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DescriptionATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM; induces H295R cell apoptosis, causes mitochondrial hyperpolarization, reactive oxygen release, and ATP depletion, caspase-3/7 activation, and membrane permeabilization; decreases the formation of cholesteryl esters and increases FC levels in H295R adrenocortical carcinoma cells; inhibits the establishment and impeds the growth of ACC-derived H295R cell xenografts in mice; orally active.Cushing Disease Phase 2 Clinical(In Vitro):Coincubation of Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride; 3 nM-30 μM) and Cholesterol markedly increases toxicity in a dose-dependent manner, where 3 nM Nevanimibe in the presence of 60 μg/mL Cholesterol reduces survival by 60% after 24 hours. All doses of Nevanimibe (3 nM-30 μM) induces cytoxicity in the presence of Cholesterol, whereas treatment with Cholesterol in the absence of Nevanimibe has no effect on cell viability.
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In VitroCell Cytotoxicity Assay Cell Line:The H295R and HAC clone 15 (HAC15) human ACC cell lines Concentration:3 nM-30 μM Incubation Time:24 hours Result:3 nM-3 μM exhibited no toxicity, whereas 30 μM treatment reduced survival by approximately 40% within 24 hours.
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In Vivo——
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SynonymsPD-132301 | PD132301-2 | ATR 101 | Nevanimibe
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaEndocrinology
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IndicationCushing Disease
Chemical Information
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CAS Number133825-81-7
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Formula Weight458.09
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Molecular FormulaC27H40ClN3O
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Purity>98% (HPLC)
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SolubilityDMSO : 41.67 mg/mL. 90.97 mM
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SMILESCC(C)C1=C(C(=CC=C1)C(C)C)NC(=O)NCC2(CCCC2)C3=CC=C(C=C3)N(C)C.Cl
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Chemical Name1-(2,6-diisopropylphenyl)-3-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. LaPensee CR, et al. Endocrinology. 2016 May;157(5):1775-88.
2. Trivedi BK, et al. J Med Chem. 1994 May 27;37(11):1652-9.
3. Cheng Y, et al. Endocr Relat Cancer. 2016 Apr;23(4):1-19.
molnova catalog



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