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ATN-224

CAS No. 649749-10-0

ATN-224 ( Choline tetrathiomolybdate;WTX-101 )

Catalog No. M15467 CAS No. 649749-10-0

ATN-224 (Choline tetrathiomolybdate;WTX-101) is a specific, high-affinity copper binder that inhibits CuZn superoxide dismutase 1 (SOD1) with IC50 of 0.33 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ATN-224
  • Note
    Research use only, not for human use.
  • Brief Description
    ATN-224 (Choline tetrathiomolybdate;WTX-101) is a specific, high-affinity copper binder that inhibits CuZn superoxide dismutase 1 (SOD1) with IC50 of 0.33 uM.
  • Description
    ATN-224 (Choline tetrathiomolybdate;WTX-101) is a specific, high-affinity copper binder that inhibits CuZn superoxide dismutase 1 (SOD1) with IC50 of 0.33 uM against purified bovine SOD1, leading to antiangiogenic and antitumour effects; shows no binding to calcium, iron, magnesium, zinc, or manganese ions at 1 mM; inhibits HUVEC proliferation with IC50 1.4 uM; shows a potential therapy against Wilson's disease.Other Indication Phase 3 Clinical
  • Synonyms
    Choline tetrathiomolybdate;WTX-101
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    649749-10-0
  • Formula Weight
    432.54
  • Molecular Formula
    C10H28MoN2O2S4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    S=[Mo]([S-])([S-])=S.OCC[N+](C)(C)C.OCC[N+](C)(C)C
  • Chemical Name
    2-hydroxy-N,N,N-trimethyl-ethanaminium, tetrathioxomolybdate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Juarez JC, et al. Clin Cancer Res. 2006 Aug 15;12(16):4974-82.
2. Doate F, et al. Br J Cancer. 2008 Feb 26;98(4):776-83.
3. Calderon-Aparicio A, et al. Oncotarget. 2015 Oct 6;6(30):29771-81.
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