AT13148
CAS No. 1056901-62-2
AT13148 ( AT-13148; AT13148 hydrochloride; AT13148 HCl )
Catalog No. M17130 CAS No. 1056901-62-2
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
Purity : 97%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 51 | In Stock |
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5MG | 104 | In Stock |
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10MG | 176 | In Stock |
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25MG | 313 | In Stock |
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50MG | 455 | In Stock |
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100MG | Get Quote | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameAT13148
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NoteResearch use only, not for human use.
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Brief DescriptionAT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
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DescriptionAT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. AT13148 is currently being developed by Astex Pharmaceuticals. AT131148 was identified utilizing high-throughput X-ray crystallography and fragment-based lead discovery techniques. AT13148 caused substantial blockade of AKT, p70S6K, PKA, ROCK and SGK substrate phosphorylation and induction of apoptosis in both a concentration and time-dependent manner in cancer cells with clinically relevant genetic defects both in vitro and in vivo.
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SynonymsAT-13148; AT13148 hydrochloride; AT13148 HCl
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PathwayOthers
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TargetOther Targets
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RecptorAkt1; Akt2; Akt3; PKA; ROCK1; ROCK2; p70 S6K; RSK1; SGK3
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1056901-62-2
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Formula Weight313.78
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Molecular FormulaC17H16ClN3O
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Purity97%
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SolubilityDMSO : 50 mg/mL 159.35 mM;
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SMILES[C@](O)(c1ccc(cc1)Cl)(c1ccc(cc1)c1cn[nH]c1)CN
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Chemical Name(S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yap TA, et al. Clin Y Res. 2012, 18(14), 3912-3923.
molnova catalog
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