AT13148 ( AT-13148; AT13148 hydrochloride; AT13148 HCl )

Catalog No. M17130 CAS No. 1056901-62-2

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Datasheet

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Product Name

AT13148
Note

Research use only, not for human use.
Brief Description

AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
Description

AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. AT13148 is currently being developed by Astex Pharmaceuticals. AT131148 was identified utilizing high-throughput X-ray crystallography and fragment-based lead discovery techniques. AT13148 caused substantial blockade of AKT, p70S6K, PKA, ROCK and SGK substrate phosphorylation and induction of apoptosis in both a concentration and time-dependent manner in cancer cells with clinically relevant genetic defects both in vitro and in vivo.
Synonyms

AT-13148; AT13148 hydrochloride; AT13148 HCl
Pathway

Others
Target

Other Targets
Recptor

Akt1; Akt2; Akt3; PKA; ROCK1; ROCK2; p70 S6K; RSK1; SGK3
Research Area

Cancer
Indication

——

CAS Number

1056901-62-2
Formula Weight

313.78
Molecular Formula

C17H16ClN3O
Purity

97%
Solubility

DMSO : 50 mg/mL 159.35 mM;
SMILES

[C@](O)(c1ccc(cc1)Cl)(c1ccc(cc1)c1cn[nH]c1)CN
Chemical Name

(S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol

1. Yap TA, et al. Clin Y Res. 2012, 18(14), 3912-3923.

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