AT13148

CAS No. 1056901-62-2

AT13148 ( AT-13148; AT13148 hydrochloride; AT13148 HCl )

Catalog No. M17130 CAS No. 1056901-62-2

AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.

Purity : 97%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 51 In Stock
5MG 104 In Stock
10MG 176 In Stock
25MG 313 In Stock
50MG 455 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    AT13148
  • Note
    Research use only, not for human use.
  • Brief Description
    AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
  • Description
    AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. AT13148 is currently being developed by Astex Pharmaceuticals. AT131148 was identified utilizing high-throughput X-ray crystallography and fragment-based lead discovery techniques. AT13148 caused substantial blockade of AKT, p70S6K, PKA, ROCK and SGK substrate phosphorylation and induction of apoptosis in both a concentration and time-dependent manner in cancer cells with clinically relevant genetic defects both in vitro and in vivo.
  • Synonyms
    AT-13148; AT13148 hydrochloride; AT13148 HCl
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Akt1; Akt2; Akt3; PKA; ROCK1; ROCK2; p70 S6K; RSK1; SGK3
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1056901-62-2
  • Formula Weight
    313.78
  • Molecular Formula
    C17H16ClN3O
  • Purity
    97%
  • Solubility
    DMSO : 50 mg/mL 159.35 mM;
  • SMILES
    [C@](O)(c1ccc(cc1)Cl)(c1ccc(cc1)c1cn[nH]c1)CN
  • Chemical Name
    (S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yap TA, et al. Clin Y Res. 2012, 18(14), 3912-3923.
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