AST-1306 ( —— )

Catalog No. M10245 CAS No. 1050500-29-2

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HPLC

MSDS

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Product Name

AST-1306
Note

Research use only, not for human use.
Brief Description

AST-1306 is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R.
Description

AST-1306 is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases,
Synonyms

——
Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR; EGFR (T790M/L858R); HER2/ErbB2; HER2/ErbB2; FLT1
Research Area

Cancer
Indication

Solid Tumors

CAS Number

1050500-29-2
Formula Weight

621.08
Molecular Formula

C31H26ClFN4O5S
Purity

>98%(HPLC)
Solubility

DMSO:124 mg/mL (199.65 mM); Ethanol:<1 mg/mL (<1 mM); Water：<1 mg/mL (<1 mM)
SMILES

CC1=CC=C(C=C1)S(O)(=O)=O.FC1=CC(COC2=CC=C(NC3=C4C=C(NC(=O)C=C)C=CC4=NC=N3)C=C2Cl)=CC=C1 |c:3,5,22,31,34,36,39,42,44,t:1,12,17,19,24|
Chemical Name

——

1. Xie H, et al. PLoS One. 2011, 6(7), e21487.

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