ASK1-IN-1

CAS No. 2411382-24-4

ASK1-IN-1 ( —— )

Catalog No. M28839 CAS No. 2411382-24-4

ASK1-IN-1 is an inhibitor of apoptosis signal-regulating kinase 1 which is a key mediator in the apoptotic and inflammatory cellular stress response with an IC50 of 21 nM in biochemica assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 203 Get Quote
10MG 357 Get Quote
25MG 617 Get Quote
50MG 878 Get Quote
100MG 1188 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    ASK1-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    ASK1-IN-1 is an inhibitor of apoptosis signal-regulating kinase 1 which is a key mediator in the apoptotic and inflammatory cellular stress response with an IC50 of 21 nM in biochemica assays.
  • Description
    ASK1-IN-1 is an inhibitor of apoptosis signal-regulating kinase 1 which is a key mediator in the apoptotic and inflammatory cellular stress response with an IC50 of 21 nM in biochemica assays.(In Vitro):ASK1-IN-1 shows good potency with cell IC50 of 138 nM. ASK1-IN-1 has superior CYP inhibition profile.(In Vivo):ASK1-IN-1 shows low clearance (rat Cl/Clu = 0.36/6.7 L h-1 kg-1) and good CNS penetration (rat K p,uu = 0.38). ASK1-IN-1 (10 mg/kg; p.o.) covers the cellular IC50/IC70/IC90 at trough in the brain for 12 hours of 50/115/435 mg/kg respectively.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2411382-24-4
  • Formula Weight
    405.4
  • Molecular Formula
    C19H19N9O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)n1c(-c2cccc(NC(c3cn(-c4nccnc4)nc3OC)=O)n2)nnc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Fan JY, et al. A systematic review of the botanical, phytochemical and pharmacological profile of Dracaena cochinchinensis, a plant source of the ethnomedicine "dragon's blood". Molecules. 2014;19(7):10650-10669. Published 2014 Jul 22.
molnova catalog
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