AS2541019 ( AS 2541019 )

Catalog No. M13323 CAS No. 2098906-98-8

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Product Name

AS2541019
Note

Research use only, not for human use.
Brief Description

AS2541019 is a novel potent, selective, orally active PI3Kδ inhibitor with IC50 of 20.1 nM.
Description

AS2541019 is a novel potent, selective, orally active PI3Kδ inhibitor with IC50 of 20.1 nM, >100-fold selectivity over other PI3K isoforms; inhibits Akt phosphorylation in human Ramos B cell line with IC50 of 14.3 nM, effectively inhibits anti-IgM stimulated B cell proliferation and human B cell proliferation with IC50 of 4.3 and 3.6 nM, respectively; significantly inhibits both T-dependent and T-independent de novo antibody production in peripheral blood in vivo; significantly prolongs graft survival time by inhibiting xenoreactive antibody production in rat concordant xenotransplant model.
Synonyms

AS 2541019
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

——
Indication

——

CAS Number

2098906-98-8
Formula Weight

529.59
Molecular Formula

C26H33F2N7O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N[C@H]1CC[C@H](OC2=NC(N3CCOCC3)=NC(N4C(C(F)F)=NC5=CC=CC=C45)=C2)CC1)CN(C)C
Chemical Name

N-[trans-4-({6-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-2-(morpholin-4-yl)pyrimidin-4-yl}oxy)cyclohexyl]-2-(dimethylamino)acetamide

1. Marui T, et al. Eur J Pharmacol. 2018 Mar 5. pii: S0014-2999(18)30133-X.

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