
AS1517499
CAS No. 919486-40-1
AS1517499( AS-1517499 | AS 1517499 )
Catalog No. M16599 CAS No. 919486-40-1
A novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 43 | In Stock |
![]() ![]() |
5MG | 72 | In Stock |
![]() ![]() |
10MG | 110 | In Stock |
![]() ![]() |
25MG | 222 | In Stock |
![]() ![]() |
50MG | 356 | In Stock |
![]() ![]() |
100MG | 444 | In Stock |
![]() ![]() |
200MG | Get Quote | In Stock |
![]() ![]() |
500MG | Get Quote | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NameAS1517499
-
NoteResearch use only, not for human use.
-
Brief DescriptionA novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay.
-
DescriptionA novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay; inhibits IL-4-induced Th2 differentiation of mouse spleen T cells with IC50 of 2.3 nM, without influencing Th1 differentiation induced by IL-12; completely inhibits both the antigen-induced up-regulation of RhoA and BSM hyperresponsiveness, significantly inhibits antigen-induced production of IL-13 in mice.
-
In Vitro——
-
In Vivo——
-
SynonymsAS-1517499 | AS 1517499
-
PathwayJAK/STAT Signaling
-
TargetSTAT
-
RecptorSTAT6
-
Research AreaInflammation/Immunology
-
Indication——
Chemical Information
-
CAS Number919486-40-1
-
Formula Weight397.8581
-
Molecular FormulaC20H20ClN5O2
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 35 mg/mL
-
SMILESc1ccc(cc1)CNc2c(cnc(n2)NCCc3ccc(c(c3)Cl)O)C(=O)N
-
Chemical Name5-Pyrimidinecarboxamide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]amino]-4-[(phenylmethyl)amino]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Nagashima S, et al. Bioorg Med Chem. 2007 Jan 15;15(2):1044-55.
2. Chiba Y, et al. Am J Respir Cell Mol Biol. 2009 Nov;41(5):516-24.
molnova catalog



related products
-
PM-43I
PM-43I is a selective inhibitor of STAT5/6 Src Homology 2 (SH2) domain.
-
JI069
JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1.
-
NSC 311068
NSC 311068 is a small molecule that directly tragets and inhibits STAT3/5.