AS1517499

CAS No. 919486-40-1

AS1517499( AS-1517499 | AS 1517499 )

Catalog No. M16599 CAS No. 919486-40-1

A novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 43 In Stock
5MG 72 In Stock
10MG 110 In Stock
25MG 222 In Stock
50MG 356 In Stock
100MG 444 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    AS1517499
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay.
  • Description
    A novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay; inhibits IL-4-induced Th2 differentiation of mouse spleen T cells with IC50 of 2.3 nM, without influencing Th1 differentiation induced by IL-12; completely inhibits both the antigen-induced up-regulation of RhoA and BSM hyperresponsiveness, significantly inhibits antigen-induced production of IL-13 in mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AS-1517499 | AS 1517499
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT6
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    919486-40-1
  • Formula Weight
    397.8581
  • Molecular Formula
    C20H20ClN5O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 35 mg/mL
  • SMILES
    c1ccc(cc1)CNc2c(cnc(n2)NCCc3ccc(c(c3)Cl)O)C(=O)N
  • Chemical Name
    5-Pyrimidinecarboxamide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]amino]-4-[(phenylmethyl)amino]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nagashima S, et al. Bioorg Med Chem. 2007 Jan 15;15(2):1044-55. 2. Chiba Y, et al. Am J Respir Cell Mol Biol. 2009 Nov;41(5):516-24.
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