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AS1517499

CAS No. 919486-40-1

AS1517499( AS-1517499 | AS 1517499 )

Catalog No. M16599 CAS No. 919486-40-1

A novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AS1517499
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay.
  • Description
    A novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay; inhibits IL-4-induced Th2 differentiation of mouse spleen T cells with IC50 of 2.3 nM, without influencing Th1 differentiation induced by IL-12; completely inhibits both the antigen-induced up-regulation of RhoA and BSM hyperresponsiveness, significantly inhibits antigen-induced production of IL-13 in mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AS-1517499 | AS 1517499
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT6
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    919486-40-1
  • Formula Weight
    397.8581
  • Molecular Formula
    C20H20ClN5O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 35 mg/mL
  • SMILES
    c1ccc(cc1)CNc2c(cnc(n2)NCCc3ccc(c(c3)Cl)O)C(=O)N
  • Chemical Name
    5-Pyrimidinecarboxamide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]amino]-4-[(phenylmethyl)amino]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nagashima S, et al. Bioorg Med Chem. 2007 Jan 15;15(2):1044-55. 2. Chiba Y, et al. Am J Respir Cell Mol Biol. 2009 Nov;41(5):516-24.
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