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ART558
CAS No. 2603528-97-6
ART558 ( —— )
Catalog No. M28594 CAS No. 2603528-97-6
ART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer.
Purity : >98% (HPLC)
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Size | Price / USD | Stock | Quantity |
5MG | 372 | Get Quote |
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10MG | 556 | Get Quote |
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25MG | 887 | Get Quote |
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50MG | 1197 | Get Quote |
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100MG | 1611 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameART558
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NoteResearch use only, not for human use.
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Brief DescriptionART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer.
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DescriptionART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer.(In Vitro):ART558 (5μM; 0~72 hours; BRCA2wild-type or BRCA2?/? cells) shows γH2AX accumulation in cells. ART558 (0~10 μM; 7 days; BRCA2wild-type or BRCA2?/? cells) shows synthetic lethality and a combinatorial effect with the PARPi olaparib in previously described isogenic models of BRCA1-deficiency. ART558 inhibits the major Polθ mediated DNA repair process, Theta-Mediated End Joining, without targeting NonHomologous End Joining. ART558 elicits DNA damage and synthetic lethality in BRCA1- or BRCA2-mutant tumour cells and enhances the effects of a PARP inhibitor. ART558 increases biomarkers of single-stranded DNA and synthetic lethality in 53BP1-defective cells whilst the inhibition of DNA nucleases that promote end-resection reversed these effects, implicating these in the synthetic lethal mechanism-of-action. ART558 increases the residence time of YFP-tagged full-length Polθ at sites of laserinduced DNA damage.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorACSS2
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Research Area——
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Indication——
Chemical Information
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CAS Number2603528-97-6
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Formula Weight418.4
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Molecular FormulaC21H21F3N4O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC(N(C)C1=CC(C)=CC=C1)(=O)[C@H]2N(CC[C@H]2O)C3=C(C#N)C(C(F)(F)F)=CC(C)=N3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Philippe Nakache, et al. Acss2 inhibitors and methods of use thereof. Patent. WO2019097515A1.
molnova catalog
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