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ARS-1630
CAS No. 1698055-86-5
ARS-1630( ARS1630 | ARS1620 R-atropisomer )
Catalog No. M12592 CAS No. 1698055-86-5
ARS-1630 is the R-conformational atropisomer of ARS-1620.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 178 | Get Quote |
|
| 10MG | 260 | Get Quote |
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| 25MG | 515 | Get Quote |
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| 50MG | 740 | Get Quote |
|
| 100MG | 972 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameARS-1630
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NoteResearch use only, not for human use.
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Brief DescriptionARS-1630 is the R-conformational atropisomer of ARS-1620.
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DescriptionARS-1630 is the R-conformational atropisomer of ARS-1620, 1,000-fold less potent than ARS-1620 (1.2 ± 0.6 M-1s-1) and thus acts as a unique inactive control compound.
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In VitroKRASG12C is recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this approach requires active cycling of KRASG12C between its active-GTP and inactive-GDP conformations as accessibility of the S-IIP is restricted only to the GDP-bound state. This strategy proves feasible for inhibiting mutant KRAS in vitro.
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In Vivo——
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SynonymsARS1630 | ARS1620 R-atropisomer
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PathwayMAPK/ERK Signaling
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TargetRas
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RecptorRas
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1698055-86-5
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Formula Weight430.84
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Molecular FormulaC21H17ClF2N4O2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 69 mg/mL 160.15 mM
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SMILESC=CC(N1CCN(C2=C3C=C(Cl)[C@@]([C@@]4=C(O)C=CC=C4F)=C(F)C3=NC=N2)CC1)=O.[R]
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Chemical Name(R)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Janes MR, et al. Cell. 2018 Jan 25;172(3):578-589.e17.
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