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Home - Products - MAPK/ERK Signaling - Ras - ARS-1323-alkyne

ARS-1323-alkyne

CAS No. 2436544-27-1

ARS-1323-alkyne( —— )

Catalog No. M24120 CAS No. 2436544-27-1

ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ARS-1323-alkyne
  • Note
    Research use only, not for human use.
  • Brief Description
    ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
  • Description
    ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    Ras
  • Recptor
    KRAS G12C
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2436544-27-1
  • Formula Weight
    569
  • Molecular Formula
    C28H27ClF2N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:35.71 mg/mL (62.76 mM; Need ultrasonic)
  • SMILES
    O=C(C=C)N1CCN(C2=NC(NCCC(N(C)CC#C)=O)=NC3=C(F)C(C4=C(O)C=CC=C4F)=C(Cl)C=C23)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lou K,et al. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 May 28;12(583). pii: eaaw9450.
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