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ARS-1323-alkyne
CAS No. 2436544-27-1
ARS-1323-alkyne( —— )
Catalog No. M24120 CAS No. 2436544-27-1
ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 433 | In Stock |
|
| 10MG | 732 | In Stock |
|
| 25MG | 1413 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameARS-1323-alkyne
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NoteResearch use only, not for human use.
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Brief DescriptionARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
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DescriptionARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetRas
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RecptorKRAS G12C
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Research Area——
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Indication——
Chemical Information
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CAS Number2436544-27-1
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Formula Weight569.0
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Molecular FormulaC28H27ClF2N6O3
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Purity>98% (HPLC)
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SolubilityDMSO:35.71 mg/mL (62.76 mM; Need ultrasonic)
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SMILESO=C(C=C)N1CCN(C2=NC(NCCC(N(C)CC#C)=O)=NC3=C(F)C(C4=C(O)C=CC=C4F)=C(Cl)C=C23)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lou K,et al. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 May 28;12(583). pii: eaaw9450.
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