ARN19702
CAS No. 1971937-18-4
ARN19702 ( —— )
Catalog No. M28741 CAS No. 1971937-18-4
ARN19702 is a selective, orally active, reversible, and brain-penetrant?N-acylethanolamine acid amidase (NAAA)?inhibitor with an?IC50?of 230 nM for?human NAAA. ARN19702 has pain relief effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 110 | Get Quote |
|
10MG | 177 | Get Quote |
|
25MG | 350 | Get Quote |
|
50MG | 560 | Get Quote |
|
100MG | 880 | Get Quote |
|
200MG | 1188 | Get Quote |
|
500MG | 1764 | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameARN19702
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NoteResearch use only, not for human use.
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Brief DescriptionARN19702 is a selective, orally active, reversible, and brain-penetrant?N-acylethanolamine acid amidase (NAAA)?inhibitor with an?IC50?of 230 nM for?human NAAA. ARN19702 has pain relief effects.
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DescriptionARN19702 is a selective, orally active, reversible, and brain-penetrant?N-acylethanolamine acid amidase (NAAA)?inhibitor with an?IC50?of 230 nM for?human NAAA. ARN19702 has pain relief effects.(In Vivo):In male mice, administration of ARN19702 (3-10 mg/kg; p.o.) daily for 7 consecutive days decreases nociception associated with Paclitaxel-induced neuropathy without the development of subacute antinociceptive tolerance. Administration of ARN19702 (0.1-30 mg/kg; p.o.) attenuates dose-dependently the spontaneous nocifensive response elicited by intraplantar formalin injection and the hypersensitivity caused by intraplantar carrageenan injection, paw incision, or sciatic nerve ligation. Administration of ARN19702 (3-10 mg/kg; p.o.) also produces remarkable protective effects against multiple sclerosis in mice.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorDHODH
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Research Area——
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Indication——
Chemical Information
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CAS Number1971937-18-4
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Formula Weight447.5
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Molecular FormulaC21H22FN3O3S2
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Purity>98% (HPLC)
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Solubility——
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SMILESCCS(=O)(=O)c1ccccc1C(=O)N1CCN(C[C@@H]1C)c1nc2ccc(F)cc2s1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lucas-Hourani M, et al.Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).J Med Chem. 2015 Jul 23;58(14):5579-98.
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