ARN19702

CAS No. 1971937-18-4

ARN19702 ( —— )

Catalog No. M28741 CAS No. 1971937-18-4

ARN19702 is a selective, orally active, reversible, and brain-penetrant?N-acylethanolamine acid amidase (NAAA)?inhibitor with an?IC50?of 230 nM for?human NAAA. ARN19702 has pain relief effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 110 Get Quote
10MG 177 Get Quote
25MG 350 Get Quote
50MG 560 Get Quote
100MG 880 Get Quote
200MG 1188 Get Quote
500MG 1764 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    ARN19702
  • Note
    Research use only, not for human use.
  • Brief Description
    ARN19702 is a selective, orally active, reversible, and brain-penetrant?N-acylethanolamine acid amidase (NAAA)?inhibitor with an?IC50?of 230 nM for?human NAAA. ARN19702 has pain relief effects.
  • Description
    ARN19702 is a selective, orally active, reversible, and brain-penetrant?N-acylethanolamine acid amidase (NAAA)?inhibitor with an?IC50?of 230 nM for?human NAAA. ARN19702 has pain relief effects.(In Vivo):In male mice, administration of ARN19702 (3-10 mg/kg; p.o.) daily for 7 consecutive days decreases nociception associated with Paclitaxel-induced neuropathy without the development of subacute antinociceptive tolerance. Administration of ARN19702 (0.1-30 mg/kg; p.o.) attenuates dose-dependently the spontaneous nocifensive response elicited by intraplantar formalin injection and the hypersensitivity caused by intraplantar carrageenan injection, paw incision, or sciatic nerve ligation. Administration of ARN19702 (3-10 mg/kg; p.o.) also produces remarkable protective effects against multiple sclerosis in mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    DHODH
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1971937-18-4
  • Formula Weight
    447.5
  • Molecular Formula
    C21H22FN3O3S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCS(=O)(=O)c1ccccc1C(=O)N1CCN(C[C@@H]1C)c1nc2ccc(F)cc2s1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lucas-Hourani M, et al.Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).J Med Chem. 2015 Jul 23;58(14):5579-98.
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