ARA290

CAS No. 1208243-50-8

ARA290 ( Cibinetide )

Catalog No. M29894 CAS No. 1208243-50-8

ARA290 is a nonerythropoietic peptide engineered from erythropoietin,, and used for neurological disease treatment.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 447 In Stock
10MG 651 In Stock
25MG 1017 In Stock
50MG 1368 In Stock
100MG 1782 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock

Biological Information

  • Product Name
    ARA290
  • Note
    Research use only, not for human use.
  • Brief Description
    ARA290 is a nonerythropoietic peptide engineered from erythropoietin,, and used for neurological disease treatment.
  • Description
    ARA290 is a nonerythropoietic peptide engineered from erythropoietin,, and used for neurological disease treatment.(In Vitro):ARA290 enhances the proliferation, migration, and resistance to H2O2-induced apoptosis of endothelial colony-forming cells (ECFCs). ARA290 is an EPO-analog peptide without hematopoietic side-effects but may have neurotrophic and antidepressant effects.(In Vivo):After ECFC transplantation to mice with CLI, a single ARA290 injection enhances the ischemic/non-ischemic ratio of hindlimb blood flow and capillary density after 28 days and the homing of radiolabeled transplanted cells to the ischemic leg 4?h after transplantation. ARA290 (30 μg/kg, s.c.) prevents progressive worsening of glucose control without affecting body weight of rats. ARA290 significantly decreases glucose AUCs in IPGTT in GK rats. Low-dosage ARA290 (35 μg/kg, i.p.) treatment only slightly attenuates the EAE severity in rats. ARA290-treating group (70 μg/kg, i.p.) significantly delays the onset, decreases the neurologic severity and shortens the duration of EAE in a dose-dependent way.
  • Synonyms
    Cibinetide
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1208243-50-8
  • Formula Weight
    1257.3
  • Molecular Formula
    C51H84N16O21
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 34 mg/mL (27.04 mM)
  • SMILES
    ——
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Hache G, et al. ARA290, a Specific Agonist of Erythropoietin/CD131 Heteroreceptor, Improves Circulating Endothelial Progenitors' Angiogenic Potential and Homing Ability. Shock. 2016 Oct;46(4):390-7
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