ARA290

CAS No. 1208243-50-8

ARA290 ( Cibinetide )

Catalog No. M29894 CAS No. 1208243-50-8

ARA290 is a nonerythropoietic peptide engineered from erythropoietin,, and used for neurological disease treatment.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 447 In Stock
10MG 651 In Stock
25MG 1017 In Stock
50MG 1368 In Stock
100MG 1782 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    ARA290
  • Note
    Research use only, not for human use.
  • Brief Description
    ARA290 is a nonerythropoietic peptide engineered from erythropoietin,, and used for neurological disease treatment.
  • Description
    ARA290 is a nonerythropoietic peptide engineered from erythropoietin,, and used for neurological disease treatment.(In Vitro):ARA290 enhances the proliferation, migration, and resistance to H2O2-induced apoptosis of endothelial colony-forming cells (ECFCs). ARA290 is an EPO-analog peptide without hematopoietic side-effects but may have neurotrophic and antidepressant effects.(In Vivo):After ECFC transplantation to mice with CLI, a single ARA290 injection enhances the ischemic/non-ischemic ratio of hindlimb blood flow and capillary density after 28 days and the homing of radiolabeled transplanted cells to the ischemic leg 4?h after transplantation. ARA290 (30 μg/kg, s.c.) prevents progressive worsening of glucose control without affecting body weight of rats. ARA290 significantly decreases glucose AUCs in IPGTT in GK rats. Low-dosage ARA290 (35 μg/kg, i.p.) treatment only slightly attenuates the EAE severity in rats. ARA290-treating group (70 μg/kg, i.p.) significantly delays the onset, decreases the neurologic severity and shortens the duration of EAE in a dose-dependent way.
  • Synonyms
    Cibinetide
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1208243-50-8
  • Formula Weight
    1257.3
  • Molecular Formula
    C51H84N16O21
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 34 mg/mL (27.04 mM)
  • SMILES
    ——
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Hache G, et al. ARA290, a Specific Agonist of Erythropoietin/CD131 Heteroreceptor, Improves Circulating Endothelial Progenitors' Angiogenic Potential and Homing Ability. Shock. 2016 Oct;46(4):390-7
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