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AR-A014418
CAS No. 487021-52-3
AR-A014418( AR-AO 14418 | AR 0133418 | AR 014418 | GSK 3β inhibitor )
Catalog No. M14634 CAS No. 487021-52-3
A potent, specific ATP-competitive inhibitor of GSK-3β with Ki/IC50 of 38/104 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 41 | In Stock |
|
| 10MG | 48 | In Stock |
|
| 25MG | 82 | In Stock |
|
| 50MG | 149 | In Stock |
|
| 100MG | 259 | In Stock |
|
| 200MG | 336 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAR-A014418
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific ATP-competitive inhibitor of GSK-3β with Ki/IC50 of 38/104 nM.
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DescriptionA potent, specific ATP-competitive inhibitor of GSK-3β with Ki/IC50 of 38/104 nM; shows no significantly inhibition on CDK2, CDK5 (IC50>100 uM) or 26 other kinases; inhibits tau phosphorylation at a GSK3-specific site (Ser-396) in cells and protects N2A neuroblastoma cells against cell death mediated by inhibition of PI3K/Akt pathway.
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In Vitro——
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In Vivo——
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SynonymsAR-AO 14418 | AR 0133418 | AR 014418 | GSK 3β inhibitor
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PathwayPI3K/Akt/mTOR signaling
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TargetGSK-3
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RecptorGSK-3β
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number487021-52-3
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Formula Weight308.3131
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Molecular FormulaC12H12N4O4S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCOc1ccc(cc1)CNC(=O)Nc2ncc(s2)[N+](=O)[O-]
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Chemical NameUrea, N-[(4-methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bhat R, et al. J Biol Chem. 2003 Nov 14;278(46):45937-45.
2. Martins DF, et al. J Pain. 2011 Mar;12(3):315-22.
3. Mazzardo-Martins L, et al. Neuroscience. 2012 Dec 13;226:411-20.
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