APD-371 ( Olorinab;APD371;APD 371 )

Catalog No. M11128 CAS No. 1268881-20-4

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Datasheet

HNMR

HPLC

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Product Name

APD-371
Note

Research use only, not for human use.
Brief Description

APD-371 (APD371, Olorinab)is a potent, selective and orally available CB2 agonist with EC50 of 6.2 nM; displays no activity against CB1 receptors (EC50>10 uM).
Description

APD-371 (APD371, Olorinab)is a potent, selective and orally available CB2 agonist with EC50 of 6.2 nM; displays no activity against CB1 receptors (EC50>10 uM); exhibits activity in rat model of osteoarthritis pain.Pain Phase 2 Clinical
Synonyms

Olorinab;APD371;APD 371
Pathway

GPCR/G Protein
Target

Cannabinoid Receptor
Recptor

Cannabinoid Receptor
Research Area

Neurological Disease
Indication

Pain

CAS Number

1268881-20-4
Formula Weight

357.41
Molecular Formula

C18H23N5O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=NN(C2=C[N+]([O-])=CC=N2)C3=C1C[C@@]4([H])[C@]3([H])C4)N[C@H](CO)C(C)(C)C
Chemical Name

3-((4aS,5aS)-3-(((S)-1-hydroxy-3,3-dimethylbutan-2-yl)carbamoyl)-4,4a,5,5a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazol-1-yl)pyrazine 1-oxide

1. Sangdon Han, et al. ACS Med. Chem. Lett., 2017, 8 (12), pp 1309-1313.

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