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APD-371

CAS No. 1268881-20-4

APD-371 ( Olorinab;APD371;APD 371 )

Catalog No. M11128 CAS No. 1268881-20-4

APD-371 (APD371, Olorinab)is a potent, selective and orally available CB2 agonist with EC50 of 6.2 nM; displays no activity against CB1 receptors (EC50>10 uM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    APD-371
  • Note
    Research use only, not for human use.
  • Brief Description
    APD-371 (APD371, Olorinab)is a potent, selective and orally available CB2 agonist with EC50 of 6.2 nM; displays no activity against CB1 receptors (EC50>10 uM).
  • Description
    APD-371 (APD371, Olorinab)is a potent, selective and orally available CB2 agonist with EC50 of 6.2 nM; displays no activity against CB1 receptors (EC50>10 uM); exhibits activity in rat model of osteoarthritis pain.Pain Phase 2 Clinical
  • Synonyms
    Olorinab;APD371;APD 371
  • Pathway
    GPCR/G Protein
  • Target
    Cannabinoid Receptor
  • Recptor
    Cannabinoid Receptor
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    1268881-20-4
  • Formula Weight
    357.41
  • Molecular Formula
    C18H23N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=NN(C2=C[N+]([O-])=CC=N2)C3=C1C[C@@]4([H])[C@]3([H])C4)N[C@H](CO)C(C)(C)C
  • Chemical Name
    3-((4aS,5aS)-3-(((S)-1-hydroxy-3,3-dimethylbutan-2-yl)carbamoyl)-4,4a,5,5a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazol-1-yl)pyrazine 1-oxide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sangdon Han, et al. ACS Med. Chem. Lett., 2017, 8 (12), pp 1309-1313.
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