AP1903

CAS No. 195514-63-7

AP1903 ( Rimiducid;AP-1903 )

Catalog No. M13061 CAS No. 195514-63-7

AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 177 Get Quote
5MG 285 Get Quote
10MG 420 Get Quote
25MG 691 Get Quote
50MG 972 Get Quote
100MG 1305 Get Quote
500MG 2601 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    AP1903
  • Note
    Research use only, not for human use.
  • Brief Description
    AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM.
  • Description
    AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM; displaces the Fluoresceinated FK506 probe from F36V-FKBP with an IC50 of 5 nM, but shows negligible binding activity to the wild-type protein; elicited potent and dose-dependent apoptotic death of human fibrosarcoma line HT1080 expressing dimerizer-dependent Fas constructs with EC50 of 0.1 nM; induces activation of Fas signaling both in vitro and in vivo, AP1903 is a lipid-permeant dimerizing ligand induced oligomerization and activation of FKBP.Blood Cancer Phase 3 Clinical
  • Synonyms
    Rimiducid;AP-1903
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    195514-63-7
  • Formula Weight
    1411.65
  • Molecular Formula
    C78H98N4O20
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 54 mg/mL 38.25 mM
  • SMILES
    O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCC(NCCNC(COC4=CC=CC([C@H](OC([C@H]5N(C([C@H](C6=CC(OC)=C(OC)C(OC)=C6)CC)=O)CCCC5)=O)CCC7=CC=C(OC)C(OC)=C7)=C4)=O)=O)=C3)CCC8=CC=C(OC)C(OC)=C8
  • Chemical Name
    (S,2R,2'R)-(1R,1'R)-((((ethane-1,2-diylbis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) bis(1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Clackson T, et al. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10437-42.
2. Richard RE, et al. Blood. 2000 Jan 15;95(2):430-6.
3. Thomis DC, et al. Blood. 2001 Mar 1;97(5):1249-57.
4. Narayanan P, et al. J Clin Invest. 2011 Apr;121(4):1524-34.
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