AP1903
CAS No. 195514-63-7
AP1903 ( Rimiducid;AP-1903 )
Catalog No. M13061 CAS No. 195514-63-7
AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 177 | Get Quote |
|
5MG | 285 | Get Quote |
|
10MG | 420 | Get Quote |
|
25MG | 691 | Get Quote |
|
50MG | 972 | Get Quote |
|
100MG | 1305 | Get Quote |
|
500MG | 2601 | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameAP1903
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NoteResearch use only, not for human use.
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Brief DescriptionAP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM.
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DescriptionAP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM; displaces the Fluoresceinated FK506 probe from F36V-FKBP with an IC50 of 5 nM, but shows negligible binding activity to the wild-type protein; elicited potent and dose-dependent apoptotic death of human fibrosarcoma line HT1080 expressing dimerizer-dependent Fas constructs with EC50 of 0.1 nM; induces activation of Fas signaling both in vitro and in vivo, AP1903 is a lipid-permeant dimerizing ligand induced oligomerization and activation of FKBP.Blood Cancer Phase 3 Clinical
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SynonymsRimiducid;AP-1903
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number195514-63-7
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Formula Weight1411.65
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Molecular FormulaC78H98N4O20
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 54 mg/mL 38.25 mM
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SMILESO=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCC(NCCNC(COC4=CC=CC([C@H](OC([C@H]5N(C([C@H](C6=CC(OC)=C(OC)C(OC)=C6)CC)=O)CCCC5)=O)CCC7=CC=C(OC)C(OC)=C7)=C4)=O)=O)=C3)CCC8=CC=C(OC)C(OC)=C8
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Chemical Name(S,2R,2'R)-(1R,1'R)-((((ethane-1,2-diylbis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) bis(1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Clackson T, et al. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10437-42.
2. Richard RE, et al. Blood. 2000 Jan 15;95(2):430-6.
3. Thomis DC, et al. Blood. 2001 Mar 1;97(5):1249-57.
4. Narayanan P, et al. J Clin Invest. 2011 Apr;121(4):1524-34.
2. Richard RE, et al. Blood. 2000 Jan 15;95(2):430-6.
3. Thomis DC, et al. Blood. 2001 Mar 1;97(5):1249-57.
4. Narayanan P, et al. J Clin Invest. 2011 Apr;121(4):1524-34.
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