AOB2796

Research use only, not for human use.

AOB2796 is a novel PAR2 agonist; activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM.

AC-55541 is a protease-activated receptor (PAR) 2 agonist. AC-55541activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM. AC-55541 was well absorbed when administered intraperitoneally to rats, each reaching micromolar peak plasma concentrations. AC-55541 was stable to metabolism by liver microsomes and maintained sustained exposure in rats, with elimination half-lives of 6.1. Systemic administration of either AC-55541 or AC-264613 produced a similar degree of hyperalgesia as was observed when the compounds were administered locally. AC-55541 may be useful in probing the physiological functions of PAR2 receptors.

AC-55541 (100 nM; 1 hour) suppresses poly I:C–induced CXCL10 mRNA in NHBE cells. RT-PCR Cell Line:NHBE cells Concentration:100 nM (prior to poly I:C stimulation)Incubation Time:1 hour Result:Poly I:C-induced CXCL10 mRNA was suppressed.

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AC-55541 | AC 55541 | AC55541

Others

Other Targets

Protease-Activated Receptor 2

Others-Field

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916170-19-9

518.36

C25H20BrN5O3

>98% (HPLC)

DMSO : ≥ 51 mg/mL;;98.39 mM

C/C(=N\NC(=O)C(c1n[nH]c(=O)c2ccccc12)NC(=O)c1ccccc1)/c1cc(ccc1)Br

(E)-N-(2-(2-(1-(3-bromophenyl)ethylidene)hydrazinyl)-2-oxo-1-(4-oxo-3,4-dihydrophthalazin-1-yl)ethyl)benzamide

(-20℃)

With Ice Pack

≥ 2 years