AOB2796

CAS No. 916170-19-9

AOB2796 ( AC-55541; AC 55541; AC55541 )

Catalog No. M17660 CAS No. 916170-19-9

AOB2796 is a novel PAR2 agonist; activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 77 In Stock
10MG 133 In Stock
25MG 228 In Stock
50MG 339 In Stock
100MG 502 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    AOB2796
  • Note
    Research use only, not for human use.
  • Brief Description
    AOB2796 is a novel PAR2 agonist; activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM.
  • Description
    AC-55541 is a protease-activated receptor (PAR) 2 agonist. AC-55541activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM. AC-55541 was well absorbed when administered intraperitoneally to rats, each reaching micromolar peak plasma concentrations. AC-55541 was stable to metabolism by liver microsomes and maintained sustained exposure in rats, with elimination half-lives of 6.1. Systemic administration of either AC-55541 or AC-264613 produced a similar degree of hyperalgesia as was observed when the compounds were administered locally. AC-55541 may be useful in probing the physiological functions of PAR2 receptors.
  • Synonyms
    AC-55541; AC 55541; AC55541
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Protease-Activated Receptor 2
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    916170-19-9
  • Formula Weight
    518.36
  • Molecular Formula
    C25H20BrN5O3
  • Purity
    98%
  • Solubility
    DMSO : ≥ 51 mg/mL;;98.39 mM
  • SMILES
    C/C(=N\NC(=O)C(c1n[nH]c(=O)c2ccccc12)NC(=O)c1ccccc1)/c1cc(ccc1)Br
  • Chemical Name
    (E)-N-(2-(2-(1-(3-bromophenyl)ethylidene)hydrazinyl)-2-oxo-1-(4-oxo-3,4-dihydrophthalazin-1-yl)ethyl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gardell LR, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):799-808.
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