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ANA-12

CAS No. 219766-25-3

ANA-12( ANA12 | ANA 12 | ANA-12 )

Catalog No. M17439 CAS No. 219766-25-3

ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ANA-12
  • Note
    Research use only, not for human use.
  • Brief Description
    ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.
  • Description
    ANA-12 is aTrkB receptor antagonist. ANA-12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and TrkC functions. Systemic administration of ANA-12 to adult mice decreased TrkB activity in the brain without affecting neuronal survival. Mice administered ANA-12 demonstrated reduced anxiety- and depression-related behaviors on a variety of tests predictive of anxiolytic and antidepressant properties in humans. ANA-12 may be a valuable tool for studying BDNF/TrkB signaling and may constitute a lead compound for developing the next generation of therapeutic agents for the treatment of mood disorders.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ANA12 | ANA 12 | ANA-12
  • Pathway
    Immunology/Inflammation
  • Target
    LTR
  • Recptor
    TrkB
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    219766-25-3
  • Formula Weight
    407.49
  • Molecular Formula
    C22H21N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 9.09 mg/mL. 22.31 mM;H2O : < 0.1 mg/mL
  • SMILES
    O=C(Nc1ccccc1C(=O)NC1CCCCNC1=O)c1cc2ccccc2s1
  • Chemical Name
    N-(2-((2-oxoazepan-3-yl)carbamoyl)phenyl)benzo[b]thiophene-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cazorla M, et al. J Clin Invest. 2011, 121(5), 1846-1857.
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