AMPK-Activator-13 ( MDK 4624; AMPKα1 activator C13; C13, Compound 13. )

Catalog No. M10984 CAS No. 1243184-62-4

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HNMR

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Product Name

AMPK-Activator-13
Note

Research use only, not for human use.
Brief Description

A potent, allosteric, α1-selective small molecule activator of AMPK (EC50=20 nM).
Description

A potent, allosteric, α1-selective small molecule activator of AMPK (EC50=20 nM); inhibits de novo lipogenesis in cellular and animal models of hyperlipidemia; the cell-permeable prodrug of compound 2 (AMPK-Activator-2).
Synonyms

MDK 4624; AMPKα1 activator C13; C13, Compound 13.
Pathway

Membrane Transporter/Ion Channel
Target

AMPK
Recptor

AMPK
Research Area

——
Indication

——

CAS Number

1243184-62-4
Formula Weight

431.33
Molecular Formula

C17H22NO10P
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)C(OCOP(C1=CC=C(C(C2)=NOC2=O)O1)(OCOC(C(C)C)=O)=O)=O
Chemical Name

(((5-(5-oxo-4,5-dihydroisoxazol-3-yl)furan-2-yl)phosphoryl)bis(oxy))bis(methylene) bis(2-methylpropanoate)

1. Hunter RW, et al. Chem Biol. 2014 Jul 17;21(7):866-79.
2. Gómez-Galeno JE, et al. ACS Med Chem Lett. 2010 Aug 30;1(9):478-82.

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