AMG319

CAS No. 1608125-21-8

AMG319 ( AMG-319;AMG 319 )

Catalog No. M12313 CAS No. 1608125-21-8

AMG319 (AMG-319) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 18 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 38 Get Quote
5MG 61 Get Quote
10MG 102 Get Quote
25MG 215 Get Quote
50MG 368 Get Quote
100MG 536 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    AMG319
  • Note
    Research use only, not for human use.
  • Brief Description
    AMG319 (AMG-319) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 18 nM.
  • Description
    AMG319 (AMG-319) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 18 nM, displays >80-fold selectivity over PI3Kα/β/γ (IC50=3300/2700/850 nM); exhibits an IC50 of 16 nM in human whole blood assay (HWB), excellent selectivity over a large panel of protein kinases; inhibits anti-IgM induced AKT phosphorylation (Ser473) in mouse B cells with IC50 of 1.5 nM, inhibits anti-IgM/CD40L-induced B cell proliferation with IC50 of 8.6 nM; exhibits in vivo efficacy in rodent disease models of inflammation.Solid Tumors Phase 2 Clinical
  • Synonyms
    AMG-319;AMG 319
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    PI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
  • Research Area
    Cancer
  • Indication
    Solid Tumors

Chemical Information

  • CAS Number
    1608125-21-8
  • Formula Weight
    385.40
  • Molecular Formula
    C21H16FN7
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C[C@H](NC1=C2N=CNC2=NC=N1)C3=CC4=CC=C(F)C=C4N=C3C5=NC=CC=C5
  • Chemical Name
    3-Quinolinemethanamine, 7-fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-, (αS)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cushing TD, et al. J Med Chem. 2015 Jan 8;58(1):480-511.
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