AMG319
CAS No. 1608125-21-8
AMG319 ( AMG-319;AMG 319 )
Catalog No. M12313 CAS No. 1608125-21-8
AMG319 (AMG-319) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 18 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 38 | Get Quote |
|
5MG | 61 | Get Quote |
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10MG | 102 | Get Quote |
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25MG | 215 | Get Quote |
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50MG | 368 | Get Quote |
|
100MG | 536 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameAMG319
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NoteResearch use only, not for human use.
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Brief DescriptionAMG319 (AMG-319) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 18 nM.
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DescriptionAMG319 (AMG-319) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 18 nM, displays >80-fold selectivity over PI3Kα/β/γ (IC50=3300/2700/850 nM); exhibits an IC50 of 16 nM in human whole blood assay (HWB), excellent selectivity over a large panel of protein kinases; inhibits anti-IgM induced AKT phosphorylation (Ser473) in mouse B cells with IC50 of 1.5 nM, inhibits anti-IgM/CD40L-induced B cell proliferation with IC50 of 8.6 nM; exhibits in vivo efficacy in rodent disease models of inflammation.Solid Tumors Phase 2 Clinical
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SynonymsAMG-319;AMG 319
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number1608125-21-8
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Formula Weight385.40
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Molecular FormulaC21H16FN7
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC[C@H](NC1=C2N=CNC2=NC=N1)C3=CC4=CC=C(F)C=C4N=C3C5=NC=CC=C5
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Chemical Name3-Quinolinemethanamine, 7-fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-, (αS)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cushing TD, et al. J Med Chem. 2015 Jan 8;58(1):480-511.
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