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AMG1

CAS No. 903591-53-7

AMG1( AMG 1 | AMG-1 )

Catalog No. M16497 CAS No. 903591-53-7

A novel specific CRAC channel inhibitor that blocks function of effector.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AMG1
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel specific CRAC channel inhibitor that blocks function of effector.
  • Description
    A novel specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo; potently suppresses SOCE following anti-CD3 stimulation in Th1, Th17 and iTreg cells at 100 nM, strongly reduces SOCE in Th1, Th17 and iTreg cells and significantly attenuates IFN-γ and IL-17 production in human CD4+ T cells with IC50 of 1792 nM and 57 nM, respectively; shows potential for Th1/Th17-mediated autoimmune diseases.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AMG 1 | AMG-1
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    903591-53-7
  • Formula Weight
    413.732
  • Molecular Formula
    C18H9ClF5N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC(=C(C(=C1)F)C(=O)NC2=NC=C(N=C2)C3=C(C=CC(=C3)C(F)(F)F)Cl)F
  • Chemical Name
    N-(5-(2-chloro-5-(trifluoromethyl)phenyl)-2-pyrazinyl)-2,6-difluorobenzamid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kaufmann U, et al. J Immunol. 2016 Jan 15;196(2):573-85.
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