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AMG-579

CAS No. 1227067-61-9

AMG-579 ( AMG 579;AMG579 )

Catalog No. M10873 CAS No. 1227067-61-9

AMG-579 is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 77 Get Quote
5MG 129 Get Quote
10MG 203 Get Quote
25MG 375 Get Quote
50MG 557 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
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Biological Information

  • Product Name
    AMG-579
  • Note
    Research use only, not for human use.
  • Brief Description
    AMG-579 is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM.
  • Description
    AMG-579 is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM; displays high selectivity with IC50 > 30 uM against all other PDE isoforms; demonstrates excellent target occupancy efficacy in PCP-LMA behavioral model.Schizophrenia Phase 1 Clinical
  • Synonyms
    AMG 579;AMG579
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE
  • Research Area
    Neurological Disease
  • Indication
    Schizophrenia

Chemical Information

  • CAS Number
    1227067-61-9
  • Formula Weight
    441.49
  • Molecular Formula
    C25H23N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC=C(OC2=NC=CN=C2C3CCN(C(C)=O)CC3)C=C1)C4=NC5=CC=CC=C5N4
  • Chemical Name
    1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hu E, et al. J Med Chem. 2014 Aug 14;57(15):6632-41.
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