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AMG-25
CAS No. 1003311-62-3
AMG-25( 3-(2-Aminoquinazolin-6-yl)-4-methyl-1-(4-(oxazol-2-yl)phenyl)pyridin-2(1H)-one | 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]pyridin-2-one )
Catalog No. M23209 CAS No. 1003311-62-3
AMG-25 is a novel selective and potent c-Kit inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 374 | In Stock |
|
| 50MG | 1737 | In Stock |
|
| 100MG | 2628 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAMG-25
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NoteResearch use only, not for human use.
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Brief DescriptionAMG-25 is a novel selective and potent c-Kit inhibitor.
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DescriptionAMG-25 is a novel selective and potent c-Kit inhibitor.
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In Vitroc-Kit-IN-5 (compound 25) shows more than 200-fold selectivity against KDR, p38, Lck, and Src (IC50=>5.0, 40, 7.8 , and >5.0 μM, respectively).
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In Vivoc-Kit-IN-5 (compound 25) (1 mg/kg; i.v.) exhibits CL (0.46 L/h/kg) and Vdss (1.59 L/kg) in rats.c-Kit-IN-5 (10 mg/kg; p.o.) exhibits AUC0-t(9860 ng?h/mL) Cmax(1230 ng/mL), T1/2 (2.6 h), and F (39%) in rats.
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Synonyms3-(2-Aminoquinazolin-6-yl)-4-methyl-1-(4-(oxazol-2-yl)phenyl)pyridin-2(1H)-one | 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]pyridin-2-one
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PathwayAngiogenesis
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Targetc-Kit
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RecptorKit
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Research Area——
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Indication——
Chemical Information
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CAS Number1003311-62-3
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Formula Weight395.41
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Molecular FormulaC23H17N5O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (63.23 mM)
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SMILESCC(C=CN1c(cc2)ccc2-c2ncco2)=C(c2cc3cnc(N)nc3cc2)C1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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