Cart
sales@molnova.com
AMG-25
CAS No. 1003311-62-3
AMG-25( 3-(2-Aminoquinazolin-6-yl)-4-methyl-1-(4-(oxazol-2-yl)phenyl)pyridin-2(1H)-one | 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]pyridin-2-one )
Catalog No. M23209 CAS No. 1003311-62-3
AMG-25 is a novel selective and potent c-Kit inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 374 | In Stock |
|
| 50MG | 1737 | In Stock |
|
| 100MG | 2628 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAMG-25
-
NoteResearch use only, not for human use.
-
Brief DescriptionAMG-25 is a novel selective and potent c-Kit inhibitor.
-
DescriptionAMG-25 is a novel selective and potent c-Kit inhibitor.
-
In Vitroc-Kit-IN-5 (compound 25) shows more than 200-fold selectivity against KDR, p38, Lck, and Src (IC50=>5.0, 40, 7.8 , and >5.0 μM, respectively).
-
In Vivoc-Kit-IN-5 (compound 25) (1 mg/kg; i.v.) exhibits CL (0.46 L/h/kg) and Vdss (1.59 L/kg) in rats.c-Kit-IN-5 (10 mg/kg; p.o.) exhibits AUC0-t(9860 ng?h/mL) Cmax(1230 ng/mL), T1/2 (2.6 h), and F (39%) in rats.
-
Synonyms3-(2-Aminoquinazolin-6-yl)-4-methyl-1-(4-(oxazol-2-yl)phenyl)pyridin-2(1H)-one | 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]pyridin-2-one
-
PathwayAngiogenesis
-
Targetc-Kit
-
RecptorKit
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1003311-62-3
-
Formula Weight395.41
-
Molecular FormulaC23H17N5O2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 25 mg/mL (63.23 mM)
-
SMILESCC(C=CN1c(cc2)ccc2-c2ncco2)=C(c2cc3cnc(N)nc3cc2)C1=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
molnova catalog
related products
-
CHMFL-KIT-031
CHMFL-KIT-031 is a highly selective KIT kinase primary V559D mutant inhibitor with IC50/Kd of 28/266 nM.
-
Amuvatinib
A novel RTK inhibitor that effectively inhibits c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively.
-
CS-2660
CS-2660, a highly selective, orally available, well tolerated VEGFR2 inhibitor with IC50 of 40 nM, inhibits closely related tyrosine kinases such as Ret and Kit with IC50 of 180 nM and 500 nM.
