AMG-1694( —— )

Catalog No. M33262 CAS No. 1361217-07-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

AMG-1694
Note

Research use only, not for human use.
Brief Description

AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM.
Description

AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals.
In Vitro

AMG-1694 is highly effective in restoring the enzymatic activity of GK with an EC50 of 0.020?μM in the presence of GKRP.
In Vivo

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Synonyms

——
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Glucokinase
Recptor

Glucokinase
Research Area

——
Indication

——

CAS Number

1361217-07-3
Formula Weight

533.63
Molecular Formula

C23H30F3N3O4S2
Purity

>98% (HPLC)
Solubility

——
SMILES

C([C@@H]1N(CCN(S(=O)(=O)C2=CC=CS2)C1)C3=CC=C([C@@](C(F)(F)F)(C)O)C=C3)N4[C@@H](C)COCC4
Chemical Name

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1. Lloyd DJ, et al. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. Nature. 2013 Dec 19;504(7480):437-40.?

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