
AM-8123
CAS No. 2049973-02-4
AM-8123( —— )
Catalog No. M35118 CAS No. 2049973-02-4
AM-8123 is an orally available nonpeptide APJ agonist.AM-8123 reduces collagen load and improves cardiac function.
Purity : >98% (HPLC)






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2MG | 445 | Get Quote |
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5MG | 686 | Get Quote |
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10MG | 938 | Get Quote |
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25MG | 1398 | Get Quote |
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50MG | 1822 | Get Quote |
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Biological Information
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Product NameAM-8123
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NoteResearch use only, not for human use.
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Brief DescriptionAM-8123 is an orally available nonpeptide APJ agonist.AM-8123 reduces collagen load and improves cardiac function.
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DescriptionAM-8123 is an orally active and potent APJ agonist. AM-8123 inhibits Forskolin-stimulated cAMP production and promotes Gα protein activation. AM-8123 can be used for the research of cardiovascular disease.
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In VitroAM-8123 (100 nM) causes a rapid β-arrestin translocation from cytoplasm to plasma membrane in APJ-expressing cells. AM-8123 bound the native hAPJ receptor with low nanomolar affinity.
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In VivoAM-8123 (100 mg/kg; p.o.) results in sustained improvement in systolic function and decreases both EDV and ESV as measured by echocardiography but not by the invasive pressure-volume conductance catheter at study termination.AM-8123 (0.035, 0.09, 0.9, and 9 mg/kg; i.v.) improves cardiovascular function.AM-8123 exhibits appreciably greater oral bioavailability in rats and dogs relative to pyr-apelin-13. AM-8123 infusion results in an increase in EF, SV, and dP/dt max at submicromolar unbound plasma concentrations with minimal change in HR, indicating that acute infusion of AM-8123 is associated with an improvement in several markers of cardiac function. AM-8123 is a more potent mediator of both ERK and AKT phosphorylation relative to pyr-apelin-13.Animal Model:Lewis rats (2~3 months old) Dosage:100 mg/kg Administration:P.o.Result:Resulted in sustained improvement in systolic function.Decreased both EDV and ESV as measured by echocardiography but not by the invasive pressure-volume conductance catheter at study termination.Animal Model:Rats Dosage:0.035, 0.09, 0.9, and 9 mg/kg Administration:I.v.Result:Improved cardiovascular function.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorApelin receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2049973-02-4
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Formula Weight567.66
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Molecular FormulaC27H33N7O5S
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Purity>98% (HPLC)
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Solubility——
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SMILESN(S([C@H]([C@@H](OC(C)C)C=1N=CC(C)=CN1)C)(=O)=O)C=2N(C(=NN2)C=3C=C(C)C=NC3)C4=C(OC)C=CC=C4OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ason B, et al. Cardiovascular response to small-molecule APJ activation. JCI Insight. 2020;5(8):e132898. Published 2020 Apr 23. doi:10.1172/jci.insight.132898
molnova catalog



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