AM-8123

CAS No. 2049973-02-4

AM-8123( —— )

Catalog No. M35118 CAS No. 2049973-02-4

AM-8123 is an orally available nonpeptide APJ agonist.AM-8123 reduces collagen load and improves cardiac function.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 445 Get Quote
5MG 686 Get Quote
10MG 938 Get Quote
25MG 1398 Get Quote
50MG 1822 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    AM-8123
  • Note
    Research use only, not for human use.
  • Brief Description
    AM-8123 is an orally available nonpeptide APJ agonist.AM-8123 reduces collagen load and improves cardiac function.
  • Description
    AM-8123 is an orally active and potent APJ agonist. AM-8123 inhibits Forskolin-stimulated cAMP production and promotes Gα protein activation. AM-8123 can be used for the research of cardiovascular disease.
  • In Vitro
    AM-8123 (100 nM) causes a rapid β-arrestin translocation from cytoplasm to plasma membrane in APJ-expressing cells. AM-8123 bound the native hAPJ receptor with low nanomolar affinity.
  • In Vivo
    AM-8123 (100 mg/kg; p.o.) results in sustained improvement in systolic function and decreases both EDV and ESV as measured by echocardiography but not by the invasive pressure-volume conductance catheter at study termination.AM-8123 (0.035, 0.09, 0.9, and 9 mg/kg; i.v.) improves cardiovascular function.AM-8123 exhibits appreciably greater oral bioavailability in rats and dogs relative to pyr-apelin-13. AM-8123 infusion results in an increase in EF, SV, and dP/dt max at submicromolar unbound plasma concentrations with minimal change in HR, indicating that acute infusion of AM-8123 is associated with an improvement in several markers of cardiac function. AM-8123 is a more potent mediator of both ERK and AKT phosphorylation relative to pyr-apelin-13.Animal Model:Lewis rats (2~3 months old) Dosage:100 mg/kg Administration:P.o.Result:Resulted in sustained improvement in systolic function.Decreased both EDV and ESV as measured by echocardiography but not by the invasive pressure-volume conductance catheter at study termination.Animal Model:Rats Dosage:0.035, 0.09, 0.9, and 9 mg/kg Administration:I.v.Result:Improved cardiovascular function.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Apelin receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2049973-02-4
  • Formula Weight
    567.66
  • Molecular Formula
    C27H33N7O5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N(S([C@H]([C@@H](OC(C)C)C=1N=CC(C)=CN1)C)(=O)=O)C=2N(C(=NN2)C=3C=C(C)C=NC3)C4=C(OC)C=CC=C4OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ason B, et al. Cardiovascular response to small-molecule APJ activation. JCI Insight. 2020;5(8):e132898. Published 2020 Apr 23. doi:10.1172/jci.insight.132898
molnova catalog
related products
  • Sitafloxacin Hydrate

    Sitafloxacin (INN; also called DU-6859a) is a fluoroquinolone antibiotic that shows promise in the treatment of Buruli ulcer.

  • IWP-L6

    IWP-L6 is an extremely effective Porcn inhibitor (EC50: 0.5 nM).

  • 3,4-Dihydro-3,4-dihy...

    3,4-Dihydro-3,4-dihydroxynaphthalen-1(2H)-one is a natural product for research related to life sciences.