Cart
sales@molnova.com
ALX-1393
CAS No. 949164-09-4
ALX-1393( —— )
Catalog No. M33260 CAS No. 949164-09-4
ALX-1393 is a selective GlyT2 inhibitor that effectively reduces neuronal action potential activity in a concentration-dependent manner and inhibits the activity of spontaneous networks by inducing glycinergic tetanic currents in the abdominal horn of the spinal cord.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 2098 | In Stock |
|
| 5MG | 2660 | In Stock |
|
| 10MG | 3591 | In Stock |
|
| 25MG | 5170 | In Stock |
|
| 50MG | 6983 | In Stock |
|
| 100MG | 8883 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameALX-1393
-
NoteResearch use only, not for human use.
-
Brief DescriptionALX-1393 is a selective GlyT2 inhibitor that effectively reduces neuronal action potential activity in a concentration-dependent manner and inhibits the activity of spontaneous networks by inducing glycinergic tetanic currents in the abdominal horn of the spinal cord.
-
DescriptionALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model.
-
In Vitro——
-
In VivoALX1393 (i.c.v.; 25, 50, and 100 μg) in normal rats suppresses the late-phase response in the formalin test but does not affect motor performance. ALX1393 inhibits mechanical and cold hyperalgesia in a dose-dependent manner.
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetGlyT
-
RecptorGlyT
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number949164-09-4
-
Formula Weight395.42
-
Molecular FormulaC23H22FNO4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC(OC[C@@H](C(O)=O)N)(C1=C(OCC2=CC=CC=C2)C=CC=C1)C3=CC(F)=CC=C3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Haranishi Y, et al. The antinociceptive effect of intrathecal administration of glycine transporter-2 inhibitor ALX1393 in a rat acute pain model. Anesth Analg. 2010 Feb 1;110(2):615-21.?
molnova catalog
related products
-
PF-03463275 B
PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.
-
Bitopertin R enantio...
A potent and selective GlyT1 inhibitor with EC50 of 54 nM.
-
PF-03463275
PF-03463275 (PF 3463275) ia an orally bioavailable, centrally penetrant, potent, reversible, selective, and competitive inhibitor of the human GlyT1 transporter with Ki of 13 nM.
