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ALW-II-49-7
CAS No. 1135219-23-6
ALW-II-49-7( DDR2-IN-1 )
Catalog No. M10472 CAS No. 1135219-23-6
ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 152 | Get Quote |
|
| 10MG | 230 | Get Quote |
|
| 25MG | 417 | Get Quote |
|
| 50MG | 614 | Get Quote |
|
| 100MG | 872 | Get Quote |
|
| 500MG | 1755 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameALW-II-49-7
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NoteResearch use only, not for human use.
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Brief DescriptionALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM.
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DescriptionALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2); displays excellent overall kinase selectivity against a panel of over 350 kinases; decreases DDR2 phosphorylation but has little effect on the proliferation of DDR2 mutated cancer cell lines.
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In Vitro——
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In Vivo——
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SynonymsDDR2-IN-1
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PathwayTyrosine Kinase
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TargetDDR
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RecptorDDR
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Research Area——
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Indication——
Chemical Information
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CAS Number1135219-23-6
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Formula Weight414.388
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Molecular FormulaC21H17F3N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (241.32 mM)
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SMILESO=C(N)C1=CN=CC(NC2=CC(C(NC3=CC=CC(C(F)(F)F)=C3)=O)=CC=C2C)=C1
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Chemical Name5-((2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)amino)nicotinamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Terai H, et al. ACS Chem Biol. 2015 Dec 18;10(12):2687-96.
2. Choi Y, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70.
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