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ALK5-IN-16i
CAS No. 864375-44-0
ALK5-IN-16i( —— )
Catalog No. M16268 CAS No. 864375-44-0
A potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameALK5-IN-16i
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3.
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DescriptionA potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3; inhibits Smad2/3 phosphorylation in A549 cells (IC50=79 nM); significantly decreases Smad2 phosphorylation in mouse skin after topical application; may serves as a potential new therapy for AGA.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayTGF-beta/Smad
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TargetTGFBR
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RecptorTGFBR
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Research Area——
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Indication——
Chemical Information
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CAS Number864375-44-0
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Formula Weight427.541
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Molecular FormulaC20H21N5O2S2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Nameisobutyl ((5-(benzo[d]thiazol-6-yl)-4-(4-methylthiazol-2-yl)-1H-imidazol-2-yl)methyl)carbamate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Amada H, et al. Bioorg Med Chem. 2012 Dec 15;20(24):7128-38.
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