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ALE-0540
CAS No. 234779-34-1
ALE-0540( ALE0540 )
Catalog No. M13671 CAS No. 234779-34-1
ALE-0540 is a nerve growth factor (NGF) antagonist that inhibits the binding of NGF to TrkA or both p75 and TrkA with IC50 of 5.88 and 3.72 uM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 155 | In Stock |
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| 5MG | 223 | In Stock |
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| 10MG | 358 | In Stock |
|
| 25MG | 599 | In Stock |
|
| 50MG | 852 | In Stock |
|
| 100MG | 1152 | In Stock |
|
| 500MG | 2313 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameALE-0540
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NoteResearch use only, not for human use.
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Brief DescriptionALE-0540 is a nerve growth factor (NGF) antagonist that inhibits the binding of NGF to TrkA or both p75 and TrkA with IC50 of 5.88 and 3.72 uM, respectively.
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DescriptionALE-0540 is a nerve growth factor (NGF) antagonist that inhibits the binding of NGF to TrkA or both p75 and TrkA with IC50 of 5.88 and 3.72 uM, respectively; produces antiallodynic actions in models of neuropathic pain.Pain Discontinued.
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In Vitro——
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In Vivo——
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SynonymsALE0540
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PathwayTyrosine Kinase
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TargetTrk Receptor
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RecptorTrk Receptor
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number234779-34-1
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Formula Weight301.258
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Molecular FormulaC14H11N3O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (414.94 mM)
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SMILESc1cc2cc(cc3c2c(c1)C(=O)N(C3=O)NCCO)[N+](=O)[O-]
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Chemical Name2-(2-Hydroxyethylamino)-5-nitrobenzo[de]isoquinoline-1,3-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Owolabi JB, et al. J Pharmacol Exp Ther. 1999 Jun;289(3):1271-6.
2. Eibl JK, et al. Eur J Pharmacol. 2013 May 15;708(1-3):30-7.
3. Sheffield KS, et al. Pharmacol Res. 2016 Jan;103:292-9.
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