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AKE-72
CAS No. 2566525-18-4
AKE-72( —— )
Catalog No. M37282 CAS No. 2566525-18-4
AKE-72 is a Pan-BCR-ABL inhibitor with anti-leukemic activity.AKE-72 inhibits the proliferation of Ba/F3 cells expressing natural BCR-ABL or its T315I mutant.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 240 | Get Quote |
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| 5MG | 372 | Get Quote |
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| 10MG | 546 | Get Quote |
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| 25MG | 815 | Get Quote |
|
| 50MG | 1095 | Get Quote |
|
| 100MG | 1467 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAKE-72
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NoteResearch use only, not for human use.
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Brief DescriptionAKE-72 is a Pan-BCR-ABL inhibitor with anti-leukemic activity.AKE-72 inhibits the proliferation of Ba/F3 cells expressing natural BCR-ABL or its T315I mutant.
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DescriptionAKE-72 (compound 5) is a potent inhibitor of Pan-BCR-ABL. AKE-72 inhibits BCR-ABLWT, BCR-ABLT315, BCR-ABLE255K, BCR-ABLF3171, BCR-ABLH396P and BCR-ABLQ252H with IC50s of < 0.5, 9, 8.98, 3.12, < 1.0 and 3.88 nM, respectively. AKE-72 has anti-leukemic activity against K-562 cell line.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetBcr-Abl
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RecptorBcr-Abl
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Research Area——
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Indication——
Chemical Information
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CAS Number2566525-18-4
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Formula Weight546.59
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Molecular FormulaC30H29F3N6O
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(CC)CC2)C=3C=CC=C(C#CC4=CC=CC=5NN=C(N)C45)C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. 3-((3-amino-1H-indazol-4-yl)ethynyl)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (AKE-72), a potent Pan-BCR-ABL inhibitor including the T315I gatekeeper resistant mutant. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2228515.?
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