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AI-10-47

CAS No. 1256094-31-1

AI-10-47( 1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47 )

Catalog No. M23426 CAS No. 1256094-31-1

AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AI-10-47
  • Note
    Research use only, not for human use.
  • Brief Description
    AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM).
  • Description
    AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM).
  • In Vitro
    AI-10-47 (10 μM) weakly inhibits CBFβ-RUNX binding.AI-10-47 significantly inhibits ME-1, TUR, M0-91, THP-1 and U937 cell growth. Western Blot Analysis Cell Line:4 × 106 SEM cells.Concentration:10 μM.Incubation Time:6 h.Result:Weakly reduced CBFβ binding to RUNX1 in cells (may due to its poor solubility).
  • In Vivo
    ——
  • Synonyms
    1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    CBFβ-RUNX binding
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1256094-31-1
  • Formula Weight
    279.22
  • Molecular Formula
    C13H8F3N3O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (358.14 mM; Need ultrasonic)
  • SMILES
    FC(F)(F)OC1=CC=C2N=C(C3=NC=CC=C3)NC2=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Anuradha Illendula, et al. Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. EBioMedicine. 2016 Jun;8:117-131.
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