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AGI-1067

CAS No. 216167-82-7

AGI-1067 ( Succinobucol;AGI 1067;AGI1067 )

Catalog No. M13448 CAS No. 216167-82-7

AGI-1067 (Succinobucol) is a potent inhibitor of TNF-α-inducible expression of VCAM-1, MCP-1 and E-selectin (IC50=6,10 and 25 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 72 In Stock
25MG 147 In Stock
50MG 250 In Stock
100MG 428 In Stock
500MG 945 In Stock
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Biological Information

  • Product Name
    AGI-1067
  • Note
    Research use only, not for human use.
  • Brief Description
    AGI-1067 (Succinobucol) is a potent inhibitor of TNF-α-inducible expression of VCAM-1, MCP-1 and E-selectin (IC50=6,10 and 25 uM).
  • Description
    AGI-1067 (Succinobucol) is a potent inhibitor of TNF-α-inducible expression of VCAM-1, MCP-1 and E-selectin (IC50=6,10 and 25 uM) with concurrent antioxidant and lipid-modulating properties; inhibits atherosclerosis in LDL receptor-deficient and apolipoprotein E-deficient mice, also reduces VCAM-1 and MCP-1 mRNA levels in lungs of LPS-stimulated mice; inhibits atherosclerosis not only via its lipid-lowering effects but also by having direct anti-inflammatory effects on the vessel wall.Diabetes Phase 3 Clinical
  • Synonyms
    Succinobucol;AGI 1067;AGI1067
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    216167-82-7
  • Formula Weight
    616.92
  • Molecular Formula
    C35H52O5S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: Soluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    O=C(O)CCC(OC1=C(C(C)(C)C)C=C(SC(C)(SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)C)C=C1C(C)(C)C)=O
  • Chemical Name
    4-(4-((1-((3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl)sulfanyl)-1-methylethyl)sulfanyl)-2,6-bis(1,1-dimethylethyl)phenoxy)-4-oxobutanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sundell CL, et al. J Pharmacol Exp Ther. 2003 Jun;305(3):1116-23.
2. Meng CQ, et al. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2545-8.
3. Tardif JC, et al. Circulation. 2003 Feb 4;107(4):552-8.
4. Kunsch C, et al. J Pharmacol Exp Ther. 2004 Mar;308(3):820-9.
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