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AG18

CAS No. 118409-57-7

AG18( RG-50810 | RG-50858 | TX 825 | Tyrphostin 23 | Tyrphostin AG-18 )

Catalog No. M10624 CAS No. 118409-57-7

AG-18(RG-50810; Tyrphostin A23) inhibits EGFR with IC50 of 35 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AG18
  • Note
    Research use only, not for human use.
  • Brief Description
    AG-18(RG-50810; Tyrphostin A23) inhibits EGFR with IC50 of 35 μM.
  • Description
    AG-18(RG-50810; Tyrphostin A23) inhibits EGFR with IC50 of 35 μM.
  • In Vitro
    10 μM tyrphostin 23 causes significant inhibition of the cell proliferation caused by 1 nM and 1μM ghrelin. Tyrphostin 23 (T23) is a well-known inhibitor of protein tyrosine kinases and has been considered as potential anti-cancer drug. T23 is reported to acutely stimulate the glycolytic flux in primary cultured astrocytes. Tyrphostin 23 stimulates glycolytic flux in cultured astrocytes. Mitochondrial metabolism of brain astrocytes is accelerated by Tyrphostin 23 exposure.
  • In Vivo
    ——
  • Synonyms
    RG-50810 | RG-50858 | TX 825 | Tyrphostin 23 | Tyrphostin AG-18
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    118409-57-7
  • Formula Weight
    186.17
  • Molecular Formula
    C10H6N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 37 mg/mL (198.74 mM); DMSO: 37 mg/mL (198.74 mM)
  • SMILES
    N#C/C(C#N)=C/C1=CC=C(O)C(O)=C1
  • Chemical Name
    2-[(3,4-dihydroxyphenyl)methylene]-propanedinitrile

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gazit A, et al. J Med Chem, 1989, 32(10), 2344-2352.
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