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Home - Products - Metabolic Enzyme/Protease - Dehydrogenase - AG-636

AG-636

CAS No. 1623416-31-8

AG-636( —— )

Catalog No. M23718 CAS No. 1623416-31-8

AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AG-636
  • Note
    Research use only, not for human use.
  • Brief Description
    AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
  • Description
    AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Transgenic female 6-8-week-old CB17/Icr-Prkdcscid/IcrIcoCrl (CB17 SCID) mice injected with OCILY19 cells Dosage:10 mg/kg, 30 mg/kg, or 100 mg/kg Administration:Oral gavage; twice daily; for 14 days Result:Resulted in robust tumor growth inhibition in xenograft lymphoma tumor models.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    DHODH|DNA/RNA Synthesis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1623416-31-8
  • Formula Weight
    343.38
  • Molecular Formula
    C21H17N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:31.25 mg/mL (91.01 mM; Need ultrasonic)
  • SMILES
    O=C(C1=C(N(C)N=N2)C2=CC(C3=CC=C(C4=CC=CC=C4C)C=C3)=C1)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gabrielle McDonald, et al. Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase. Mol Cancer Ther. 2020 Dec;19(12):2502-2515.
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