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AG-270

CAS No. 2201056-66-6

AG-270 ( —— )

Catalog No. M28586 CAS No. 2201056-66-6

AG-270 is an allosteric and orally active inhibitor of MAT2A.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AG-270
  • Note
    Research use only, not for human use.
  • Brief Description
    AG-270 is an allosteric and orally active inhibitor of MAT2A.
  • Description
    AG-270 is an allosteric and orally active inhibitor of MAT2A.(In Vitro):AG-270 exhibits an IC50 of 20 nM in HCT116 MTAP-null cell SAM at 72 h.AG-270 demonstrates potent reduction in levels of intracellular SAM, as well as MTAP-null–selective antiproliferative activity in the HCT116 MTAP isogenic cell model in vitro.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2201056-66-6
  • Formula Weight
    489.6
  • Molecular Formula
    C30H27N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc(cc1)ccc1C(C(n1nc2-c3ccccc3)=O)=C(Nc3ncccc3)Nc1c2C1=CCCCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bagalagel, Alaa A.; Bogari, Hanin A.; Ahmed, Safwat A.; Diri, Reem M.; Elhady, Sameh S.[Heterocycles, 2018, vol. 96, # 4, p. 749 - 756]
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