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AG-1478

CAS No. 153436-53-4

AG-1478 ( NSC 693255; Tyrphostin AG-1478 )

Catalog No. M12161 CAS No. 153436-53-4

AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR.

Purity : >98%(HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AG-1478
  • Note
    Research use only, not for human use.
  • Brief Description
    AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR.
  • Description
    AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR.
  • Synonyms
    NSC 693255; Tyrphostin AG-1478
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR; HER2; PDGFR
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    153436-53-4
  • Formula Weight
    315.75
  • Molecular Formula
    C16H14ClN3O2
  • Purity
    >98%(HPLC)
  • Solubility
    Ethanol: 13 mg/mL (41.17 mM); DMSO: 25 mg/mL (79.17 mM)
  • SMILES
    COC1=CC2=NC=NC(NC3=CC=CC(Cl)=C3)=C2C=C1OC
  • Chemical Name
    N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Levitzki A, et al. Science, 1995, 267(5205), 1782-1788.
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