AG-1478

CAS No. 153436-53-4

AG-1478 ( NSC 693255; Tyrphostin AG-1478 )

Catalog No. M12161 CAS No. 153436-53-4

AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR.

Purity : >98%(HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 41 In Stock
10MG 55 In Stock
25MG 103 In Stock
50MG 186 In Stock
100MG 259 In Stock
200MG 337 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    AG-1478
  • Note
    Research use only, not for human use.
  • Brief Description
    AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR.
  • Description
    AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR.
  • Synonyms
    NSC 693255; Tyrphostin AG-1478
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR; HER2; PDGFR
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    153436-53-4
  • Formula Weight
    315.75
  • Molecular Formula
    C16H14ClN3O2
  • Purity
    >98%(HPLC)
  • Solubility
    Ethanol: 13 mg/mL (41.17 mM); DMSO: 25 mg/mL (79.17 mM)
  • SMILES
    COC1=CC2=NC=NC(NC3=CC=CC(Cl)=C3)=C2C=C1OC
  • Chemical Name
    N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Levitzki A, et al. Science, 1995, 267(5205), 1782-1788.
molnova catalog
related products
  • SU5402

    SU5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.

  • XL-647

    XL-647 (Tesevatinib, EXEL-7647, KD-019) is a novel spectrum-selective kinase inhibitor that potently inhibits the EGFR, ErbB2, KDR and EphB4 with IC50 of 0.3, 16, 1.5 and 1.4 nM, respectively.

  • Afatinib dimaleate

    An irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively.