AF64394( —— )

Catalog No. M21599 CAS No. 1637300-25-4

AF64394 is a selective inverse agonist of GPR3(pIC50 : 7.3).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
5MG	110	Get Quote
10MG	177	Get Quote
25MG	375	Get Quote
50MG	557	Get Quote
100MG	791	Get Quote
500MG	1611	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

AF64394
Note

Research use only, not for human use.
Brief Description

AF64394 is a selective inverse agonist of GPR3(pIC50 : 7.3).
Description

AF64394 is a selective inverse agonist of GPR3(pIC50 : 7.3).
In Vitro

AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3. AF34394 and related compounds are only of modest potency and are relatively lipophilic (e.g., AF34394 clogP=5.2, LLE=2.1, and 14b clog P=3.1 and LLE=3.2) the series shows promising SAR and represents an excellent start point for further optimization.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

GPR3
Research Area

——
Indication

——

Chemical Information

CAS Number

1637300-25-4
Formula Weight

393.87
Molecular Formula

C21H20ClN5O
Purity

>98% (HPLC)
Solubility

DMSO:125 mg/mL (317.36 mM)
SMILES

CC(C)Oc1cc(Cl)ccc1CNc1cc(nc2ncnn12)-c1ccccc1
Chemical Name

(4-Chloro-2-isopropoxy-benzyl)-(5-phenyl-[124]triazolo[15-a]pyrimidin-7-yl)-amine

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Jensen T et al. The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5195-8.

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