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AF64394

CAS No. 1637300-25-4

AF64394( —— )

Catalog No. M21599 CAS No. 1637300-25-4

AF64394 is a selective inverse agonist of GPR3(pIC50 : 7.3).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AF64394
  • Note
    Research use only, not for human use.
  • Brief Description
    AF64394 is a selective inverse agonist of GPR3(pIC50 : 7.3).
  • Description
    AF64394 is a selective inverse agonist of GPR3(pIC50 : 7.3).
  • In Vitro
    AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3. AF34394 and related compounds are only of modest potency and are relatively lipophilic (e.g., AF34394 clogP=5.2, LLE=2.1, and 14b clog P=3.1 and LLE=3.2) the series shows promising SAR and represents an excellent start point for further optimization.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GPR3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1637300-25-4
  • Formula Weight
    393.87
  • Molecular Formula
    C21H20ClN5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (317.36 mM)
  • SMILES
    CC(C)Oc1cc(Cl)ccc1CNc1cc(nc2ncnn12)-c1ccccc1
  • Chemical Name
    (4-Chloro-2-isopropoxy-benzyl)-(5-phenyl-[124]triazolo[15-a]pyrimidin-7-yl)-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jensen T et al. The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5195-8.
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