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AF64394
CAS No. 1637300-25-4
AF64394( —— )
Catalog No. M21599 CAS No. 1637300-25-4
AF64394 is a selective inverse agonist of GPR3(pIC50 : 7.3).
AF64394 is a selective inverse agonist of GPR3(pIC50 : 7.3).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 110 | Get Quote |
|
| 10MG | 177 | Get Quote |
|
| 25MG | 375 | Get Quote |
|
| 50MG | 557 | Get Quote |
|
| 100MG | 791 | Get Quote |
|
| 500MG | 1611 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAF64394
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NoteResearch use only, not for human use.
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Brief DescriptionAF64394 is a selective inverse agonist of GPR3(pIC50 : 7.3).
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DescriptionAF64394 is a selective inverse agonist of GPR3(pIC50 : 7.3).
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In VitroAF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3. AF34394 and related compounds are only of modest potency and are relatively lipophilic (e.g., AF34394 clogP=5.2, LLE=2.1, and 14b clog P=3.1 and LLE=3.2) the series shows promising SAR and represents an excellent start point for further optimization.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorGPR3
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Research Area——
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Indication——
Chemical Information
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CAS Number1637300-25-4
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Formula Weight393.87
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Molecular FormulaC21H20ClN5O
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (317.36 mM)
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SMILESCC(C)Oc1cc(Cl)ccc1CNc1cc(nc2ncnn12)-c1ccccc1
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Chemical Name(4-Chloro-2-isopropoxy-benzyl)-(5-phenyl-[124]triazolo[15-a]pyrimidin-7-yl)-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jensen T et al. The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5195-8.
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