AER-271

CAS No. 634913-39-6

AER-271( AER271 )

Catalog No. M15401 CAS No. 634913-39-6

AER-271 (AER271) is a selective, small molecule inhibitor of aquaporin-4 (AQP4), the prodrug of AER-270 with enhanced solubility.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 33 In Stock
5MG 53 In Stock
10MG 95 In Stock
25MG 205 In Stock
50MG 311 In Stock
100MG 467 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    AER-271
  • Note
    Research use only, not for human use.
  • Brief Description
    AER-271 (AER271) is a selective, small molecule inhibitor of aquaporin-4 (AQP4), the prodrug of AER-270 with enhanced solubility.
  • Description
    AER-271 (AER271) is a selective, small molecule inhibitor of aquaporin-4 (AQP4), the prodrug of AER-270 with enhanced solubility; shows improved neurological outcome and reduced swelling in two models of CNS injury complicated by cerebral edema.Other Indication Phase 1 Clinical(In Vivo):AER-271 is converted in vivo to AER-270 by endogenous phosphatases. AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest.AER-271 reduces cerebral edema and improves neurological outcomes in rodent ischemic stroke models. Mice treated with AER-271 (5?mg/kg; i.p. injection) show improved outcomes and reduced cerebral edema in a model of ischemic stroke.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male mice (C57BL/6J, 8-12?week-old, 25-30?g)Dosage:5?mg/kg Administration:Treated by i.p. injection Result:Had better outcomes with an average neurological score of 0.89±0.31 compared with control mice receiving vehicle had an average neurological score of 2.50±0.62.
  • Synonyms
    AER271
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    634913-39-6
  • Formula Weight
    463.653
  • Molecular Formula
    C15H9ClF6NO5P
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (269.60 mM)
  • SMILES
    O=P(O)(OC1=CC=C(Cl)C=C1C(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O)O
  • Chemical Name
    2-{[3,5-Bis(trifluoromethyl) phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Farr GW, et al. Neuroscience. 2019 Feb 6. pii: S0306-4522(19)30054-5. 2. Wallisch JS, et al. Pediatr Res. 2018 Oct 26. doi: 10.1038/s41390-018-0215-5.
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