AER-271
CAS No. 634913-39-6
AER-271( AER271 )
Catalog No. M15401 CAS No. 634913-39-6
AER-271 (AER271) is a selective, small molecule inhibitor of aquaporin-4 (AQP4), the prodrug of AER-270 with enhanced solubility.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 33 | In Stock |
|
5MG | 53 | In Stock |
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10MG | 95 | In Stock |
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25MG | 205 | In Stock |
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50MG | 311 | In Stock |
|
100MG | 467 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameAER-271
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NoteResearch use only, not for human use.
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Brief DescriptionAER-271 (AER271) is a selective, small molecule inhibitor of aquaporin-4 (AQP4), the prodrug of AER-270 with enhanced solubility.
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DescriptionAER-271 (AER271) is a selective, small molecule inhibitor of aquaporin-4 (AQP4), the prodrug of AER-270 with enhanced solubility; shows improved neurological outcome and reduced swelling in two models of CNS injury complicated by cerebral edema.Other Indication Phase 1 Clinical(In Vivo):AER-271 is converted in vivo to AER-270 by endogenous phosphatases. AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest.AER-271 reduces cerebral edema and improves neurological outcomes in rodent ischemic stroke models. Mice treated with AER-271 (5?mg/kg; i.p. injection) show improved outcomes and reduced cerebral edema in a model of ischemic stroke.
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In Vitro——
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In VivoAnimal Model:Male mice (C57BL/6J, 8-12?week-old, 25-30?g)Dosage:5?mg/kg Administration:Treated by i.p. injection Result:Had better outcomes with an average neurological score of 0.89±0.31 compared with control mice receiving vehicle had an average neurological score of 2.50±0.62.
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SynonymsAER271
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number634913-39-6
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Formula Weight463.653
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Molecular FormulaC15H9ClF6NO5P
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (269.60 mM)
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SMILESO=P(O)(OC1=CC=C(Cl)C=C1C(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O)O
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Chemical Name2-{[3,5-Bis(trifluoromethyl) phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Farr GW, et al. Neuroscience. 2019 Feb 6. pii: S0306-4522(19)30054-5.
2. Wallisch JS, et al. Pediatr Res. 2018 Oct 26. doi: 10.1038/s41390-018-0215-5.
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