ADX88178 ( ADX-88178; ADX 88178; ADX88178 )

Catalog No. M17210 CAS No. 1235318-89-4

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Datasheet

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Product Name

ADX88178
Note

Research use only, not for human use.
Brief Description

ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.
Description

ADX-88178 is a novel potent, selective, and brain-penetrant positive allosteric modulator of the mGlu4 receptor in rodent models of anxiety, obsessive compulsive disorder (OCD), fear, depression, and psychosis. ADX88178 dose-dependently reduced the number of buried marbles in the marble burying test and increased open-arm exploration in the elevated plus maze (EPM) test, indicative of anxiolytic-like efficacy.
Synonyms

ADX-88178; ADX 88178; ADX88178
Pathway

Others
Target

Other Targets
Recptor

human mGluR4
Research Area

——
Indication

——

CAS Number

1235318-89-4
Formula Weight

272.33
Molecular Formula

C12H12N6S
Purity

98%
Solubility

DMSO : ≥ 50 mg/mL 183.60 mM
SMILES

Cc1nc(Nc2nc(c3c[nH]nc3)c(C)s2)ncc1
Chemical Name

5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine

1. Fujinaga M, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):370-4.

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