ACTB-1003

CAS No. 939805-30-8

ACTB-1003 ( ACTB1003; ACTB 1003; ACTB-1003 )

Catalog No. M19271 CAS No. 939805-30-8

ACTB-1003 is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 123 In Stock
5MG 178 In Stock
10MG 312 In Stock
25MG 530 In Stock
50MG 758 In Stock
100MG 1044 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    ACTB-1003
  • Note
    Research use only, not for human use.
  • Brief Description
    ACTB-1003 is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).
  • Description
    ACTB-1003 is an oral kinase inhibitor targeting cancer mutations (FGFR inhibition), angiogenesis (inhibition of VEGFR2 and Tie-2) and induces apoptosis (targeting RSK and p70S6K, downstream of PI3 kinase). The multi-activity of ACTB- 1003 translates to in vivo efficacy with dose-dependent tumor growth inhibition in a variety of histological cancers including lung, breast and colorectal. ACTB-1003 is an oral kinase inhibitor with multiple modes of action, targeting cancer mutations via FGFR inhibition FGFR1 (IC50=6 nM), angiogenesis through inhibition of VEGFR2 (2 nM), Tie-2 (4 nM), and induces apoptosis likely by targeting RSK (5 nM) and p70S6K (32 nM). ACTB-1003 is highly active with dose-dependent tumor growth inhibition in cell lines with FGFR genetic alterations - OPM2 human multiple myeloma and the murine leukemia Ba/F3-TEL-FGFR1.
  • Synonyms
    ACTB1003; ACTB 1003; ACTB-1003
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    FGFR1,VEGFR2,Tie-2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    939805-30-8
  • Formula Weight
    591.54
  • Molecular Formula
    C27H26F5N7O3
  • Purity
    98%
  • Solubility
    DMSO : ≥ 35 mg/mL; 59.17 mM
  • SMILES
    COCC1=C(N2C(=C1C3=CC(=C(C=C3)NC(=O)NC4=C(C=CC(=C4)C(F)(F)F)F)F)C(=NC=N2)N)CN5CCOCC5
  • Chemical Name
    1-(4-(4-amino-6-(methoxymethyl)-7-(morpholinomethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-fluorophenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Patel K, et al. Journal of Clinicalal Oncology 28, no. 15 DOI: 10.1200/jco.2010.28.15_suppl.e13665
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